{"id":9546,"date":"2002-11-01T08:40:58","date_gmt":"2002-11-01T08:40:58","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=9546"},"modified":"2014-06-03T17:54:56","modified_gmt":"2014-06-03T17:54:56","slug":"mechanisms-of-t-cell-depletion-and-repletion-in-hiv-disease","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/9546","title":{"rendered":"Mechanisms of T-cell depletion and repletion in HIV disease"},"content":{"rendered":"<p><strong>Joseph M. McCune, MD, PhD<\/strong><\/p>\n<p><strong>More than 20 years since the beginning of the AIDS epidemic, there is still no clear-cut explanation for HIV\u2019s most basic and insidious effect in the human body: the gradual depletion of CD4+ T-lymphocytes in the absence of antiretroviral treatment. At the same time, there is little consensus regarding the mechanism(s) by which CD4+ cell counts improve once therapy is commenced.<\/strong><\/p>\n<p>On some level, the fact that CD4+ cell counts do improve\u2014both quantitatively and qualitatively\u2014with antiretroviral therapy should be enough to satisfy the hearts and minds of HIV-treating clinicians. But there is much to be gained medicinally with the continued exploration of these fundamental questions. For example, antiretroviral therapy plays a critical role in halting the accelerated destruction of CD4+ cells, perhaps the most widely accepted mechanism of HIV-associated CD4+ cell depletion. But there is also at least one other mechanism to ponder\u2014the impaired production of new CD4+ cells as a result of HIV infection\u2014that may have a significant bearing on the evaluation and potential use of various immune-based therapies in the clinical management of HIV-positive patients.Full text at:<\/p>\n<p><a href=\"http:\/\/www.prn.org\/prn_nb_cntnt\/vol7\/num3\/mccune_frm.htm\">http:\/\/www.prn.org\/prn_nb_cntnt\/vol7\/num3\/mccune_frm.htm<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Joseph M. McCune, MD, PhD More than 20 years since the beginning of the AIDS epidemic, there is still no clear-cut explanation for HIV\u2019s most basic and insidious effect in the human body: the gradual depletion of CD4+ T-lymphocytes in &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[30],"tags":[],"class_list":["post-9546","post","type-post","status-publish","format-standard","hentry","category-on-the-web"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/9546","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=9546"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/9546\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=9546"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=9546"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=9546"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}