{"id":9600,"date":"2004-07-29T00:31:48","date_gmt":"2004-07-29T00:31:48","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=9600"},"modified":"2014-05-22T17:00:03","modified_gmt":"2014-05-22T17:00:03","slug":"latent-drug-resistant-hiv-harboured-for-years","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/9600","title":{"rendered":"Latent drug-resistant HIV harboured for years"},"content":{"rendered":"<p><strong>David Douglas, HIVandHepatits.com<\/strong><\/p>\n<p><strong>Among patients who had previously shown drug resistance, drug-resistant strains of HIV still existed in blood cells even though the patients were responding successfully to highly active antiretroviral therapy (HAART), Belgian researchers recently observed.<\/strong><\/p>\n<p>Dr Chris Verhofstede and Ghent University Hospital colleagues studied 11 patients who were successfully treated with HAART for a mean of 59 months. All patients had a history of suboptimal therapy and had developed drug resistance. Of these patients, 10 still had previously evolved drug-resistant HIV detectable in peripheral blood mononuclear cells.<\/p>\n<p>\u201cWe were able to show that all drug-resistant HIV-1 variants that arise during therapy failure remain archived in the cells of the infected person for a very long period of time &#8211; at least 7 years and most probably much longer,\u201d said Verhofstede. The resistance was detectable \u201ceven if drug pressure was removed or if a patient subsequently responded well to a new drug combination.\u201d<\/p>\n<p>\u201cThese findings indicate that once resistance arises against an antiretroviral, the activity of this drug will remain reduced for several years and possibly life-long, even after a withdrawal period of years,\u201d said Verhofstede. \u201cRecycling drugs is therefore not an advisable option if other alternatives are available.\u201d He further noted that the results \u201cargue against a possible benefit of therapy interruptions as a way to improve the effect of a subsequently introduced salvage regimen containing recycled drugs.\u201d<\/p>\n<p>\u00a9 Copyright 2004 by HIV and Hepatitis.com. All Rights Reserved. Reproduction for personal or educational use is encouraged and does not require permission. Written permission is required to re-print copyrighted articles but is almost always granted (email<a href=\"mailto:publisher@HIVandHepatitis.com\">publisher@HIVandHepatitis.com<\/a>).<\/p>\n<p>Reference:<\/p>\n<p>Verhofstede C, Noe A, Demecheleer E et al. Drug-resistant variants that evolve during nonsuppressive therapy persist in HIV-1-infected peripheral blood mononuclear cells after long-term highly active antiretroviral therapy. J Acquir Immune Defic Syndr. 2004 Mar 15;35(5):473-483.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>David Douglas, HIVandHepatits.com Among patients who had previously shown drug resistance, drug-resistant strains of HIV still existed in blood cells even though the patients were responding successfully to highly active antiretroviral therapy (HAART), Belgian researchers recently observed. Dr Chris Verhofstede &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[3],"tags":[],"class_list":["post-9600","post","type-post","status-publish","format-standard","hentry","category-antiretrovirals"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/9600","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=9600"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/9600\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=9600"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=9600"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=9600"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}