{"id":9634,"date":"2004-07-29T01:07:10","date_gmt":"2004-07-29T01:07:10","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=9634"},"modified":"2014-05-22T16:53:21","modified_gmt":"2014-05-22T16:53:21","slug":"low-azt-activity-against-hiv-2-infection","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/9634","title":{"rendered":"Low AZT activity against HIV-2 infection"},"content":{"rendered":"<p><strong>Simon Collins, HIV i-Base<\/strong><\/p>\n<p><strong>Although AZT is widely used to treat HIV-2 infection recent studies showing difference in response compared to patients with HIV-1. This prompted Garcia-Lerma and colleagues from CDC Atlanta USA to evaluate in vitro selection experiments with strains of each virus.<\/strong><\/p>\n<p>5\/5 HIV-1 strains rapidly selected for resistance after 3-6 passages (in increasing AZT concentrations of four-32 fold). In contrast 0\/5 HIV-2 virus acquired mutations after 10 passages (1024-fold increase in AZT concentration). In the presence of both AZT and ddI, HIV-1 viruses selected mutation for both drugs, while HIV-2 selected only for ddI (K65R and M184V).<\/p>\n<p>All HIV-2 viruses replicated efficiently in concentration of AZT that was 2800-fold higher than the EC50 for HIV-1 and were 200-fold less sensitive. Sensitivity to ddI was similar for both HIV-1 and HIV-2.<\/p>\n<p>Reference:<\/p>\n<p>Reid P, MacInnes H, Garcia-Lerma JG et al. Natural resistance of HIV-2 to zidovudine. XIII Intl HIV Drug Resistance Workshop, 2004.\u00a0Abstract 32. Antiviral Therapy 2004; 9:S38.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Simon Collins, HIV i-Base Although AZT is widely used to treat HIV-2 infection recent studies showing difference in response compared to patients with HIV-1. This prompted Garcia-Lerma and colleagues from CDC Atlanta USA to evaluate in vitro selection experiments with &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[4,36],"tags":[110],"class_list":["post-9634","post","type-post","status-publish","format-standard","hentry","category-conference-reports","category-drug-resistance","tag-idrw-13th-2004"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/9634","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=9634"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/9634\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=9634"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=9634"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=9634"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}