{"id":9684,"date":"2004-06-02T14:35:11","date_gmt":"2004-06-02T14:35:11","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=9684"},"modified":"2014-05-22T17:12:06","modified_gmt":"2014-05-22T17:12:06","slug":"undetectable-hiv-viral-load-in-hiv-hcv-coinfected-patients-slows-liver-fibrosis-progression-rate","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/9684","title":{"rendered":"Undetectable HIV viral load in HIV-HCV coinfected patients slows liver fibrosis progression rate"},"content":{"rendered":"<p><strong>HIVandHepeatitis.com<\/strong><\/p>\n<p><strong>In the pre-HAART era, HIV-HCV-coinfected patients were reported to have a faster fibrosis progression rate (FPR) than HCV-monoinfected patients. One preliminary study suggested that HAART might slow down FPR. The study was conducted in New York City and at four sites in Puerto Rico.<\/strong><\/p>\n<p>In the current study, overall, 685 consecutive HCV-infected patients, 297 HIV-positive and 388 HIV-negative, who underwent a liver biopsy (Ishak scoring) were analysed. A known date of HCV infection was available in 675.<\/p>\n<p>In the current study, overall, 685 consecutive HCV-infected patients, 297 HIV-positive and 388 HIV-negative, who underwent a liver biopsy (Ishak scoring) were analysed. A known date of HCV infection was available in 675.<\/p>\n<p>In HIV-HCV-coinfected patients, log10 HIV RNA level was strongly correlated with FPR, but CD4+ cell count only weakly.<\/p>\n<p>HIV-HCV-coinfected patients with any HIV viral load &gt;400 copies\/ml had a faster FPR than coinfected patients with undetectable plasma HIV RNA and than HCV-monoinfected patients who in turn had a similar FPR as HIV-HCV-coinfected patients with &lt;400 copies\/ml (p=0.253).<\/p>\n<p>HIV viral load is strongly correlated with FPR in HIV-HCV-coinfected patients, but CD4+ cell count only weakly. Undetectable HIV viral load is associated with slower FPR than with any HIV level and the same as in HCV-monoinfection.<\/p>\n<h3>Comment<\/h3>\n<p><strong>This study confirms previous data published by Benhamou et al Hepatology 1999 and Quirishi et al. in The Lancet 2003 showing that patients on effective antiretroviral treatment have a slower fibrosis progression and a lower incidence of liver failure. A methodological problem is that in principle only studies with paired biopsies and not cross sectional studies can answer the questions of fibrosis progression accurately.<\/strong><\/p>\n<p>Reference:<\/p>\n<p>N Br\u00e4u and others. Control of HIV viral load through Highly Active Antiretroviral Therapy (HAART) slows down liver fibrosis progression in HIV\/HCV-coinfection and makes it the same as in HCV-monoinfection. The Puerto Rico-New York Hepatitis C Study Group. Abstract 91. 39th EASL, 14-18 April 2004, Berlin Germany.<\/p>\n<p>\u00a9 Copyright 2004 by HIV and Hepatitis.com. All Rights Reserved. Reproduction for personal or educational use is encouraged and does not require permission. Written permission is required to re-print copyrighted articles but is almost always granted (email\u00a0<a href=\"mailto:publisher@HIVandHepatitis.com\">publisher@HIVandHepatitis.com<\/a>).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>HIVandHepeatitis.com In the pre-HAART era, HIV-HCV-coinfected patients were reported to have a faster fibrosis progression rate (FPR) than HCV-monoinfected patients. One preliminary study suggested that HAART might slow down FPR. The study was conducted in New York City and at &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-9684","post","type-post","status-publish","format-standard","hentry","category-hepatitis-coinfection"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/9684","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=9684"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/9684\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=9684"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=9684"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=9684"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}