{"id":9686,"date":"2004-06-02T14:37:47","date_gmt":"2004-06-02T14:37:47","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=9686"},"modified":"2014-05-22T17:11:41","modified_gmt":"2014-05-22T17:11:41","slug":"compared-to-caucasians-africans-have-significantly-higher-rates-of-fibrosis-and-cirrhosis-despite-lower-levels-of-hbv-replication","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/9686","title":{"rendered":"Compared to Caucasians, Africans have significantly higher rates of fibrosis and cirrhosis despite lower levels of HBV replication"},"content":{"rendered":"<p><strong>HIVandHepeatitis.com<\/strong><\/p>\n<p><strong>It is believed that low HBV replication (&lt;105 copies\/ml) is indicative of mild histological lesions. In this study, French researchers aimed to assess the relationship between viral replication, histological lesions and race in HBV patients of diverse ethnic backgrounds.<\/strong><\/p>\n<p>The study group consisted of 552 chronic HBsAg carriers without other viral co-infection who had a liver biopsy. Viral replication was assessed in 516 patients by hybridisation and\/or PCR assays.<\/p>\n<p>Race was defined as African (Af, Blacks), Caucasian (Cc, Whites), Asian (As). Overall, Af had more frequent low viral replication (75%) than Cc (43%) or As (34%) (p&lt;10-3). Despite low viral replication, 20% of patients had significant fibrosis (F2F3F4), including 7.5% with cirrhosis.<\/p>\n<p>Among all patients with F2F3F4, 35% had low level replication and 16% no replication (&lt;200 copies\/ml). A third of cirrhotic patients had a low level of replication and 11% no replication.<\/p>\n<p>The interactions between viral replication and liver lesions were also modified by race. In F2F3F4 patients, the proportion of those with low viral replication was 49% in Af, which was significantly higher than in As (25%, p&lt;0.02) or Cc (26%, p=0.03). Non-Af race was associated with F2F3F4 (p=0.01) independent of male sex (p&lt;10-3) and age (p&lt;10-3). However, after adjustment for the level of viral replication the race effect disappeared.<\/p>\n<p>The authors conclude: \u201cA significant proportion of patients with chronic hepatitis B have advanced fibrosis despite a low level of HBV replication. Differences between Af and As patients suggest a considerable clinical impact of different HBV genotypes.\u201d<\/p>\n<p>Reference:<\/p>\n<p>Ratziu V et al. Low HBV replication and liver fibrosis: the impact of race in a study of 552 chronic hepatitis B patients. Abstract 440. 39th EASL, 14-18April 2004, Berlin, Germany.<\/p>\n<p>\u00a9 Copyright 2004 by HIV and Hepatitis.com. All Rights Reserved. Reproduction for personal or educational use is encouraged and does not require permission. Written permission is required to re-print copyrighted articles but is usually granted (email\u00a0<a href=\"mailto:publisher@HIVandHepatitis.com\">publisher@HIVandHepatitis.com<\/a>).<\/p>\n","protected":false},"excerpt":{"rendered":"<p>HIVandHepeatitis.com It is believed that low HBV replication (&lt;105 copies\/ml) is indicative of mild histological lesions. In this study, French researchers aimed to assess the relationship between viral replication, histological lesions and race in HBV patients of diverse ethnic backgrounds. &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[24],"tags":[],"class_list":["post-9686","post","type-post","status-publish","format-standard","hentry","category-hepatitis-coinfection"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/9686","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=9686"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/9686\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=9686"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=9686"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=9686"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}