{"id":9966,"date":"2004-02-03T09:40:47","date_gmt":"2004-02-03T09:40:47","guid":{"rendered":"http:\/\/i-base.info\/htb\/?p=9966"},"modified":"2014-05-22T19:32:00","modified_gmt":"2014-05-22T19:32:00","slug":"tenofovir-levels-in-children-approach-adult-values","status":"publish","type":"post","link":"https:\/\/i-base.info\/htb\/9966","title":{"rendered":"Tenofovir levels in children approach adult values"},"content":{"rendered":"<p><strong>Mark Mascolini, IAS News<\/strong><\/p>\n<p><strong>A study of tenofovir concentrations in HIV-infected, antiretroviral-experienced children starting this nucleotide analogue found steady-state exposures that approach those seen in adults taking 300 mg daily &#8211; approximately 3000 ng . h\/mL.<\/strong><\/p>\n<p>The trial began with 18 children stopping a failing regimen and starting only tenofovir. Incremental dosing with 75-mg tablets aimed for a target dose of 175 mg\/m2; the median administered dose was 208 mg\/m2. Single-dose studies found a geometric mean area under the concentration-time curve (AUC) of 2150 ng . h\/mL and a mean maximum concentration of 266 ng\/mL.<\/p>\n<p>Children then added other drugs to their regimen on the basis of treatment history and resistance patterns. Four weeks later, steady-state pharmacokinetic studies in 16 children showed a geometric mean AUC of 2920 ng . h\/mL, which was significantly higher than the AUC in the single-dose study (P = 0.0004). The geometric mean maximum concentration at steady state measured 302 ng\/mL.<\/p>\n<p>Source: International AIDS Society<\/p>\n<p><a href=\"http:\/\/www.ias.se\/article\/show.asp?article=2566\">http:\/\/www.ias.se\/article\/show.asp?article=2566<\/a><\/p>\n<p>Reference:<\/p>\n<p>Hazra R, Balis FM, Tullio AN et al. Single-dose and steady-state pharmacokinetics of tenofovir disoproxil fumarate in human immunodeficiency virus-infected children. Antimicrobial Agents and Chemotherapy 2004; 48:124-129.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Mark Mascolini, IAS News A study of tenofovir concentrations in HIV-infected, antiretroviral-experienced children starting this nucleotide analogue found steady-state exposures that approach those seen in adults taking 300 mg daily &#8211; approximately 3000 ng . h\/mL. The trial began with &hellip;<\/p>\n","protected":false},"author":4,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[32],"tags":[],"class_list":["post-9966","post","type-post","status-publish","format-standard","hentry","category-paediatric-care"],"_links":{"self":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/9966","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/users\/4"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/comments?post=9966"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/posts\/9966\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/media?parent=9966"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/categories?post=9966"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/htb\/wp-json\/wp\/v2\/tags?post=9966"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}