HI<\/p>\n
This is an interesting aspect of PrEP which is rarely emphasied – especially protection from oral sex if you are giving\u00a0oral sex on a man.<\/p>\n
Although there is no direct data on this that I am aware of, PrEP is likely to work for any type of sexual activity, because oral drugs are absorbed into the blood which travels around your whole body. This means it\u00a0would reach lymph nodes throughout the body, including clsoe to the mouth, and one of the places that\u00a0PrEP is thought to work is\u00a0in lymph glands.<\/p>\n
PrEP\u00a0studies have reported\u00a0absorption into vaginal and rectal tissue because being the receptive partner generally has\u00a0a higher risk than for a man who is insertive. It is also because durg absorption into these two key tissues are know to be different and this affects different levels of adherence needed for similar protection.<\/p>\n
It\u00a0is reasonable I think to assume that PrEP is\u00a0just as effective for oral sex and\u00a0for a man who is having insertive sex. This is because people are likely to have taken different roles during the PrEP studies and also would have had\u00a0oral sex.<\/p>\n
If PrEP is close to 100% effective when taken as prescribed for highest risk risk sex it will be just as effective for rsiks that are much lower.<\/p>\n
I haven’t seen any data about drug levels in other tissue sites – even from animal studies – but the level of protection is likely to be at least as good, and similar dosing advice seems reasonable.<\/p>\n
Also,\u00a0researches are still not certain of exactly how PrEP works – and which are the target levels even in anal and rectal\u00a0tissue compartments.<\/p>\n