{"id":12248,"date":"2016-10-12T21:14:55","date_gmt":"2016-10-12T21:14:55","guid":{"rendered":"http:\/\/i-base.info\/qa\/?p=12248"},"modified":"2024-08-26T15:40:32","modified_gmt":"2024-08-26T15:40:32","slug":"12248","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/12248","title":{"rendered":"Questions from a pharmacist on PEP and choice of first ART?"},"content":{"rendered":"<p>Thanks for your questions, both good ones.<\/p>\n<p>When PEP works, it stops HIV from replicating everywhere in the body. It either works or it doesn&#8217;t. HIV inside cells either dies if PEP is successful or survives if PEP doesn&#8217;t work.<\/p>\n<p>To see if PEP has worked, someone needs to wait 4 weeks after taking PEP before taking an HIV test. \u00a0During this month anyone who has taken PEP should assume that they might be HIV positive.<\/p>\n<p>For your second question, WHO guidelines are clear that Atripla or generic equivilents\u00a0are\u00a0still the leading\u00a0first line treatment and that tenofovir DF should be\u00a0included as a component of any first-line combination. It is better to use the best drugs first.<\/p>\n<p>These two guide discuss first-line and second-line treatment.<\/p>\n<ul>\n<li><a href=\"https:\/\/i-base.info\/guides\/starting\">https:\/\/i-base.info\/guides\/starting<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/guides\/changing\">https:\/\/i-base.info\/guides\/changing<\/a><\/li>\n<\/ul>\n<p>Please see this link for more information about PEP:<br \/>\n<a href=\"https:\/\/i-base.info\/qa\/factsheets\/pep-faq\">https:\/\/i-base.info\/qa\/factsheets\/pep-faq<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hello.<\/p>\n<p>1. What happens to the HIV that enters the cell after PEP is taken&#8230;..does it still circulate in the blood of the host and survives&#8230;.is it possible that someone could be infectious after taking PEP, and after how many days does anybody become non-infectious after taking PEP.<\/p>\n<p>2. While initiating ART, we usually recommend Atripla (TDF+FTC+EFV) as a first line med. But TDF is of high viral suppression power when compared to the other NRTIs&#8230;is it not possible someone started with Atripla, and develops resistance to it (due to adherence or any other reason) remains with out any other ART choices in the first line&#8230;&#8230;could it be better if we start the patient with the other NRTIs and then move to Atripla when ever necessary?<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,10,31,39],"tags":[],"class_list":["post-12248","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-changing-treatment","category-peppepse","category-starting-treatment"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/12248","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=12248"}],"version-history":[{"count":2,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/12248\/revisions"}],"predecessor-version":[{"id":23977,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/12248\/revisions\/23977"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=12248"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=12248"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=12248"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}