{"id":1524,"date":"2010-03-26T14:30:34","date_gmt":"2010-03-26T14:30:34","guid":{"rendered":"http:\/\/i-base.info\/qa\/?p=1524"},"modified":"2010-03-26T14:30:34","modified_gmt":"2010-03-26T14:30:34","slug":"why-is-my-viral-load-fluctuating-so-much","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/1524","title":{"rendered":"Why is my viral load fluctuating so much?"},"content":{"rendered":"<p>Thank you for your question.<\/p>\n<p>Please don\u2019t be scared. When to start treatment is a big decision and it is great that you are actively seeking the information you need to make that decision.<\/p>\n<p>You should speak to your doctor about a confirmatory test. It is important that you continue to monitor your CD4 and viral load results over the next few months to see what happens.<\/p>\n<p>There are several possible reasons for your sudden increase in viral load. Firstly there could be an additional underlying infection. Secondly it could just be a viral load \u2018blip\u2019 which is where a sudden increase in viral load is seen and then it goes back down again. Unfortunately we do not yet know what causes this.<\/p>\n<p>Finally it is possible that there was a mistake made with your lab results. The viral load test first multiplies the amount of virus found in the blood so that it can be counted. This means mistakes are easy to make. There is a 3-fold margin of error with viral load test which means that your results of 240,000 could be anywhere between 80,000 and 720,000copies\/ml.<\/p>\n<p>It is not usually the case that the higher the viral load the higher the risk of sickness. It is more the lower the CD4 the higher the risk of sickness as the CD4 count is measuring the state of your immune system. If the CD4 count is low then your immune system is also low and you are more likely to get sick. A CD4 count of 580 is still very good.<\/p>\n<p>When to start treatment is your decision to be made in consultation with your doctor. You should not feel that anything is a barrier to your starting treatment.<\/p>\n<p>If you are thinking of starting treatment you may find it useful to read the i-Base \u2018<a href=\"https:\/\/i-base.info\/home\/combination-therapy-guide\/\">Introduction to Combination Therapy<\/a>\u2019 guide.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I was diagnosed HIV positive in early 2007. The results of my CD4 counts and viral load (VL) tests so far are as follows:<\/p>\n<p>CD4=700, VL=6,000<\/p>\n<p>CD4=580, VL=7,000<\/p>\n<p>CD4=900, VL=24,000<\/p>\n<p>CD4=580, VL=240,000<\/p>\n<p>These are from the first test up to the most recent one. The last two are the most recent tests taken three months apart. I am concerned about the huge difference between these two. I am especially concerned about the rise in VL from 24,000 to 240,000 in the space of three months. I just wonder if this is normal. Is it not supposed to be a steady increase?<\/p>\n<p>This really scares me as my doctor is reluctant to start me on HIV medication as my CD4 seems to be okay. As far as I understand, the higher the VL, the higher the risk of sickness. Would it not be better in this case to start treatment irrespective of the CD4 count? I am trying to be sensible and keep going for tests but looking at this, I am scared I am going to get sick anyway because the CD4 is blocking me from starting treatment.<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,9,39],"tags":[],"class_list":["post-1524","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-cd4-and-viral-load","category-starting-treatment"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/1524","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=1524"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/1524\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=1524"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=1524"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=1524"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}