{"id":174,"date":"2007-08-24T12:15:33","date_gmt":"2007-08-24T11:15:33","guid":{"rendered":"http:\/\/www.i-base.info\/qa\/?p=174"},"modified":"2021-11-22T12:18:43","modified_gmt":"2021-11-22T12:18:43","slug":"what-drugs-can-i-use-in-my-next-treatment-and-what-drugs-are-coming-next","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/174","title":{"rendered":"What drugs can I use in my next treatment and what drugs are coming next?"},"content":{"rendered":"<p>Hi<\/p>\n<p>Your choices will depend on your previous treatment history, the side effects you had before, and when you need to start treatment.<\/p>\n<p>If Sustiva (efavirenz) and Kivexa (abacavir + 3TC) combination was your first ever treatment, and when you stopped treatment your viral load was undetectable &#8211; ie this was just for side effects and that you haven&#8217;t developed resistance &#8211; then you have a lot of choice based on already approved drugs.<\/p>\n<p>If the reason you stopped treatment was related to Kivexa &#8211; especially if you had a hypersensitivity reaction (rash, fever etc) then you can;t use this drug again.<\/p>\n<p>If you stopped because of Sustiva&#8217;s side effects (sleep disturbance, nightmares, mood swings, increased anxiety or depression etc) then Kivexa is fine to use again but you need to chose a different third drug.<\/p>\n<p>Depending on your viral load and CD4 count, this could be:<\/p>\n<ul>\n<li>atazanavir\/ritonavir (boosted Reyataz) &#8211; a once-daily protease inhibitor<\/li>\n<li>lopinavir\/r (Kaletra) &#8211; a twice daily protease inhibitor<\/li>\n<li>nevirapine (Viramune) &#8211; a twice-daily NNRTI<\/li>\n<li>darunavir\/r &#8211; an approved protease inhibitor that was developed to be used in people with a lot of resistance, but which came out better against Kaletra in a recent trial of people in earlier treatment.<\/li>\n<\/ul>\n<p>The information in the i-Base <a href=\"https:\/\/i-base.info\/guides\/changing\/\">&#8216;Changing treatment&#8217; <\/a>guide should also be useful<\/p>\n<p>If you want to research drugs that will be available in the UK over the next year or so, these are likely to include:<\/p>\n<ul>\n<li>maraviroc &#8211; a CCR5 inhibitor  recently approved in the US<\/li>\n<li>raltegravir &#8211; an integrase inhibitor not yet approved but which has produced very good early results in both people on their first treatment and people who have drug resistance<\/li>\n<li>etravirine &#8211; a new NNRTI<\/li>\n<\/ul>\n<p>Most of these drugs are being developed for people who have resistance to current drugs &#8211; though raltegravir has shown promising results in an early treatment naive study.<\/p>\n<p>For recent reports about any of these treatments, try searching the i-Base website. Articles from the i-Base HIV Treatment Bulletin reports latest results from trials and conferences, though the language is fairly medical.<\/p>\n<p>Other community-based sites with good information on each drug include:<\/p>\n<ul>\n<li><a href=\"http:\/\/www.aidsmeds.com\">Aidsmeds<\/a><\/li>\n<li><a href=\"http:\/\/www.aidsmap.com\">Aidsmap<\/a><\/li>\n<li><a href=\"http:\/\/www.aidsinfonet.org\">AidsInfonet<\/a><\/li>\n<li><a href=\"http:\/\/www.hivandhepatitis.com\">HIV and Hepatitis<\/a><\/li>\n<li><a href=\"http:\/\/www.natap.org\">NATAP<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>I have recently stopped my HIV Treatment (Sustiva; and Kivexa, due to side effects) for a treatment break.<\/p>\n<p>I am now considering starting a new regime but I would rather look in to the drugs that could be available next so i may research them myself.<\/p>\n<p>Do you have any suggestions of what could be next, or to what I should ask why doctor about?<\/p>\n<p>Many thanks,<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,10,35,38],"tags":[],"class_list":["post-174","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-changing-treatment","category-resistance","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/174","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=174"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/174\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=174"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=174"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=174"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}