{"id":18769,"date":"2021-12-03T14:59:02","date_gmt":"2021-12-03T14:59:02","guid":{"rendered":"https:\/\/i-base.info\/qa\/?p=18769"},"modified":"2024-08-26T15:24:06","modified_gmt":"2024-08-26T15:24:06","slug":"switching-between-tdf-and-taf-for-pep","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/18769","title":{"rendered":"Switching between TDF and TAF for PEP."},"content":{"rendered":"<p>Hi, how are you doing?<\/p>\n<p>There are no guidelines in the UK, or suggested by WHO that TAF should be used as PEP. TDF has been associated with renal failure although this is rare, often the side effects reverse once having stopped the medication.<\/p>\n<p>Are you aware if you already have problems with your kidneys? TDF is not recommended in people with an eGFR below 80, eGFR being a measure of how your kidneys function.<\/p>\n<p>TAF does have a lower risk of causing side effects that TDF but as it is not a recommended medication for PEP, you will need to discuss this with your prescribing doctor. The effect of TAF on LDL is still being studied. As it is often taken in combination it is difficult to directly link changes in LDL to the switch of TAF and TDF. It has also been suggested that maybe TDF reduces LDL and switching to TAF loses this positive side effect.<\/p>\n<p>Please see this link for more information about PEP:<br \/>\n<a href=\"https:\/\/i-base.info\/qa\/factsheets\/pep-faq\">https:\/\/i-base.info\/qa\/factsheets\/pep-faq<\/a><\/p>\n<p>If you have any more questions please feel free to get in touch,<\/p>\n<p>Josh.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>My doctor has prescribed TDF\/Emtricitabine\/Dolutegravir for PEP and also mentioned another alternative where I can replace TDF with TAF.<\/p>\n<p>I&#8217;ve taken the TDF drugs for 14 days, but after seeing a study which says that there is a risk of renal impairment from TDF (300 mg) regimen even when taken for a month, I&#8217;ve been thinking of switching to TAF alternative.<\/p>\n<p>I want to know if switching to TAF for 14 days is a safer alternative and if there are any risks associated with it? I&#8217;ve read that TAF increases the LDL cholesterol but will it cause any significant impact if taken for 14 days?<\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,10,31,38],"tags":[],"class_list":["post-18769","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-changing-treatment","category-peppepse","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/18769","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=18769"}],"version-history":[{"count":1,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/18769\/revisions"}],"predecessor-version":[{"id":23956,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/18769\/revisions\/23956"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=18769"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=18769"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=18769"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}