Thank you for your question.<\/p>\n
Truvada contains FTC and tenofovir, both of which also work to treat hepatitis B. This means you do not need to continue with the Zeffix especially if your hepatitis B has now been cured.<\/p>\n
If you have been taking Zeffix (lamivudine) without any other HIV medications then your HIV is likely to be resistant to this drug now. Lamivudine and FTC (one of the drugs in Truvada) have similar resistance profiles. This means that the HIV is probably also resistant to FTC. If you take Truvada and efavirenz then you will only have two drugs that work on the HIV. This may still be ok, as some research suggests that this resistance (called M184V) is less active.<\/p>\n
HIV can become more easily resistant to\u00a0efavirenz (Sustiva) compared to a boosted protease inhibitor, if the combinations does not include three active drugs. So starting your HIV treatment with Truvada with efavirenz could cause resistance problems in the future.<\/p>\n
Talk to your doctor about combining the Truvada with a boosted protease inhibitor instead. It is harder for HIV to become resistant to protease inhibitors and so this combination will be a more effective option in your situation.<\/p>\n","protected":false},"excerpt":{"rendered":"
I have on Zeffix (lamivudine, 3TC) for two years to treat my hepatitis B. I have now cured hepatitis B. I am due to start HIV medication in a few weeks. They want to start me on Truvada (tenofovir and FTC) with efavirenz (Sustiva). I want to know when I start this medication if I should stop taking the Zeffix or not?<\/p>\n
Please answer me soon. Thank you.<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,10,13,35,39],"tags":[],"class_list":["post-1902","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-changing-treatment","category-complications-and-coinfections","category-resistance","category-starting-treatment"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/1902","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=1902"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/1902\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=1902"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=1902"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=1902"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}