{"id":19062,"date":"2022-01-24T12:09:25","date_gmt":"2022-01-24T12:09:25","guid":{"rendered":"https:\/\/i-base.info\/qa\/?p=19062"},"modified":"2024-08-26T15:12:28","modified_gmt":"2024-08-26T15:12:28","slug":"long-term-side-effects-from-pep","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/19062","title":{"rendered":"Long term side effects from PEP"},"content":{"rendered":"<p>Hi, how are you doing?<\/p>\n<p>The side effects you have mentioned are associated with these medications when on long-term use. Having 5 courses of 10 years is not going to lead to these complications. Your doctor was right to treat the course of PEP as safe.<\/p>\n<p>During PEP side-effects are often noted to be short term and resolve when the course ends. There will have been no long-term effect to your genetic material. You are safe to have children.<\/p>\n<p>Truvada is linked to kidney function loss. However, this is assessed long term and can present within 6 months of starting. In your case you were not on it longer than 28 days at a time. Are you aware of of any kidney problems you had before starting PEP? Filtering 10% under average does not indicate loss of function. As it&#8217;s an average many people will fall into the same bracket as you are are very healthy.<\/p>\n<p>Please see this link for more information about PEP:<br \/>\n<a href=\"https:\/\/i-base.info\/qa\/factsheets\/pep-faq\">https:\/\/i-base.info\/qa\/factsheets\/pep-faq<\/a><\/p>\n<p>Josh.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I took PEP (Truvada and Isentress) five times in the last 10 years for 21 to 28 days each time. My doctor treated them as very safe and I suffer from anxiety, so it was prescribed after every situation of low risk with someone of unknown status. I&#8217;m a heterosexual male in my 40s, I have read the side effects which include bone density loss, kidney problems and even cancer from Isentress. Do you see those side effects could present in my case? Will these drugs affect my genetic material if I want to have kids? My kidneys are filtering 10% under average for my age but can&#8217;t prove that it wasn&#8217;t like that before taking these meds. Thank you for your help!<\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,31,38],"tags":[],"class_list":["post-19062","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-peppepse","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/19062","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=19062"}],"version-history":[{"count":2,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/19062\/revisions"}],"predecessor-version":[{"id":23934,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/19062\/revisions\/23934"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=19062"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=19062"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=19062"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}