Hi, how are you doing?<\/p>\n
Delstrigo and Symtuza and both single-pill combinations used to manage HIV-1. The difference between them is what medications are used to make them.<\/p>\n
Delstrigo = doravirine, lamivudine and tenofovir DF.\u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Symtuza = darunavir, cobicistat, emtricitabine and tenofovir AF.<\/p>\n
Different studies have looked to identify how effective each of these drugs are. There is no study which directly demonstrated which is more effective by direct comparison. With undetectable viral load as the goal, a study compared Delstrigo vs Atripla in 728 patients. In 48 weeks, 84% of those on Delstrigo achieved this goal whereas 80% of those on Atripla acheived this.<\/p>\n
A similar study used to identify the efficacy of Symtuza involving 153 patients was conducted with undetectable viral load as the primary endpoint. Over 24 weeks Symtuza acheived undetectable viral load in 75% of patients. This compared well to the control achveing undetectable viral load in 74% of patients.<\/p>\n
As the timeline of each study differs a direct comparison cannot be made however they have both been demonstrated to offer equal or superior effectiveness in attaining undetectable viral load.<\/p>\n
A major difference of note is that Symtuza is ‘boosted’ while Delstrigo is not. This means the combination of Symtuza contains an extra medication to boost how effective another drug is. In this case cobicistat boosting daranuvir.\u00a0Boosted combinations are generally less well tolerated by people than other options available.<\/p>\n
Both Delstrigo and Symtuza are not recommened as being first line. Instead they are both available as switch options. Meaning that when someone achieves undetectable viral load on their current regiment, they are able to switch to either of these. This switch factoring in adherence, access, suitability and cost.<\/p>\n
Josh.<\/p>\n","protected":false},"excerpt":{"rendered":"
What are the differences between Delstrigo and Symtuza – is one more effective than the other?<\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,10],"tags":[],"class_list":["post-19254","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-changing-treatment"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/19254","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=19254"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/19254\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=19254"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=19254"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=19254"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}