Hi, how are you doing?<\/p>\n
As you have stated, it is difficult to say among individuals due to how variable CD4 count is. This means I cannot provide a general value for a bigger picture.<\/p>\n
In most cases it can take between 2-10 years for CD4 count to fall below 200. Outside of this it can be within months to more than 15 years.<\/p>\n
A CD4\/Cd8 ratio is determined by the value of CD4 cells to CD8. There should be 2 CD8 cells for every 1 CD4 cell.<\/p>\n
Starting from a lower CD4 cell count it takes longer for the cells to recover. As an example it can be less than a year to go from 400 to 500, but from 100 to 500 it can take multiple years.<\/p>\n
The ratio is not often used clinically because it doesn’t offer too much information about how your immune system is functioning. If you naturally have a lower Cd8 count it can provide a skewed result.<\/p>\n
Josh.<\/p>\n","protected":false},"excerpt":{"rendered":"
Dear all,<\/p>\n
May I inquire about the duration during which an untreated patient will have a CD4\/CD8 ratio of less than 1? Is it 1, 2, 5 years or more?<\/p>\n
I understand that CD4 levels can vary among individuals, but could you provide a general overview of the big picture regarding them?<\/p>\n
If the patient starts treatment, how frequently can the ratio be expected to return to normal (more than 1)? I understand that the ratio may not be of paramount importance, but I am curious about it.<\/p>\n
Thank you<\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,9],"tags":[],"class_list":["post-22378","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-cd4-and-viral-load"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/22378","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=22378"}],"version-history":[{"count":1,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/22378\/revisions"}],"predecessor-version":[{"id":22379,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/22378\/revisions\/22379"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=22378"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=22378"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=22378"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}