{"id":22786,"date":"2024-01-29T22:18:00","date_gmt":"2024-01-29T22:18:00","guid":{"rendered":"https:\/\/i-base.info\/qa\/?p=22786"},"modified":"2024-10-14T09:20:22","modified_gmt":"2024-10-14T09:20:22","slug":"will-on-demand-dosing-work","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/22786","title":{"rendered":"Will 2:1:1 PrEP dosing work?"},"content":{"rendered":"<p>Hi, how are you doing?<\/p>\n<p>Thanks for writing out the dosing schedule: 2 pills on Tuesday 9pm, Wednesday 9am sex, 1 pill Thursday morning 9am, Friday morning 5am.<\/p>\n<p>This means you were 12 hours late with PrEP?<\/p>\n<p>Do you know if this was a &#8216;risky&#8217; exposure e.g., HIV positive partner with high viral load, other STIs, drugs etc&#8230;?<\/p>\n<p>Some PrEP is always going to be better than no PrEP and as the first dose was a double dose there is some protection afforded for longer than 24 hours.<\/p>\n<p>The same level of protection cannot be guaranteed as if taken as recommended but it can still reduce the risk of HIV.<\/p>\n<p>The gap of 12 hours is going to have some impact on how effective PrEP is but the initial double dose will help with this.<\/p>\n<p>Josh.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hi, I am on the 2-1-1 protocol.  On Tuesday night I took 2 pills, Wednesday morning had sex, didn\u2019t take the pills Wednesday night because to my horror I left my pills in my locker at work, I immediately took the missed dose the following morning (Thursday) and then my 3rd dose early Friday morning.  How bad is this?  Here\u2019s the dosing schedule that occurred.<\/p>\n<p>2 pills on Tuesday 9pm, Wednesday 9am sex, 1 pill Thursday morning 9am, Friday morning 5am. <\/p>\n","protected":false},"author":18,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,7,23,51],"tags":[],"class_list":["post-22786","post","type-post","status-publish","format-standard","hentry","category-adherence","category-all-topics","category-hiv-transmission","category-prep"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/22786","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/18"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=22786"}],"version-history":[{"count":2,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/22786\/revisions"}],"predecessor-version":[{"id":22847,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/22786\/revisions\/22847"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=22786"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=22786"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=22786"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}