Hello and many thanks for getting in touch.<\/p>\n
Kidney function can be reduced throughout our life and in most cases this is not permanent.<\/p>\n
Age, medication, dehydration (not having enough fluid intake) can affect the kidney function.<\/p>\n
What the eGFR shows:<\/p>\n
eGFR shows how fast can your kidneys remove toxins or other waste from your blood.<\/p>\n
It is calculated based on your race\/ethnicity, weight and height, sex, age and creatinine level.<\/p>\n
An eGFR over 60\u00a0mL\/min\/1.73m2 is considered quite good although in the UK the only result within normal range is over 90 mL\/min\/1.73m2.<\/p>\n
To answer your question about Dovato, your doctor is giving you good advice, in my opinion.<\/p>\n
Dovato is the best kidney-sparing combination \u00a0we have available right now.<\/p>\n
Sometimes people who take certain medication present lower kidney function on the blood tests but that effect is not present when they are taken off the medication. A very good example\u00a0for that are the creatine supplements\u00a0that people take for the gym: the tests present reduced kidney function but if you stop them a week before getting tested the results are back to normal range.<\/p>\n
Similarly, dolutegravir increases the creatinine in your blood so it makes your eGFR show a reduced value.<\/p>\n
This is to be expected and doesn’t affect your kidneys long-term.<\/p>\n
The drugs in Dovato<\/span> (dolutegravir\u00a0+ lamivudine) have not had any kidney – toxic effect in any studies.<\/p>\n Please let us know how you are getting on.<\/p>\n","protected":false},"excerpt":{"rendered":" My kidney function is slightly reduced lately with my eGFR coming down to 75 and my doctor suggested to switch to Dovato (Dolutegravir – Lamivudine). Is this a good option for me?<\/p>\n","protected":false},"author":20,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[10,13,30],"tags":[],"class_list":["post-25783","post","type-post","status-publish","format-standard","hentry","category-changing-treatment","category-complications-and-coinfections","category-other-tests"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/25783","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/20"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=25783"}],"version-history":[{"count":3,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/25783\/revisions"}],"predecessor-version":[{"id":25790,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/25783\/revisions\/25790"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=25783"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=25783"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=25783"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}