{"id":26591,"date":"2026-03-26T13:17:52","date_gmt":"2026-03-26T13:17:52","guid":{"rendered":"https:\/\/i-base.info\/qa\/?p=26591"},"modified":"2026-03-27T21:12:26","modified_gmt":"2026-03-27T21:12:26","slug":"does-a-late-211-dose-mean-i-need-pep","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/26591","title":{"rendered":"Does a late third dose on 2:1:1 PrEP mean I need PEP?"},"content":{"rendered":"<p>Hi there<\/p>\n<p>Please do not\u00a0worry about this.<\/p>\n<p>The following information should help you decide on the need for PEP.<\/p>\n<ul>\n<li>This doesn&#8217;t sound like any risk for HIV?<\/li>\n<li>The initial double dose provides very good drug levels to cover slightly later doses.<\/li>\n<li>The doses afterwards would still have covered you well.<\/li>\n<\/ul>\n<p>Based on this situation, UK guidelines would include any need to use PEP.<\/p>\n<p>Please these links for info on PrEP and PEP:<\/p>\n<ul>\n<li><a href=\"https:\/\/i-base.info\/guides\/prep\">i-base.info\/guides\/prep<\/a><\/li>\n<li><a href=\"https:\/\/i-base.info\/qa\/factsheets\/pep-faq\">i-base.info\/qa\/factsheets\/pep-faq<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>Hi &#8211; I\u2019m on the 2-1-1 on-demand PrEP regimen: I took 2 tablets at time 0 (the initial loading dose), then 1 tablet at 32 hours (8 hours late, instead of the scheduled 24-hour dose), then 1 tablet at 48 hours. I plan to take one more tablet at 7 PM this afternoon.<\/p>\n<p>I had unprotected receptive anal intercourse, where I was the receptive partner (the one being penetrated). The other person inserted for only 5 minutes, but there was a brief moment of fast penetration right at the start that caused me pain once. I don\u2019t know his HIV status and he did not ejaculate.<\/p>\n<p>Do I need to start PEP as my third PrEP dose was taken 8 hours late?<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,7,51],"tags":[],"class_list":["post-26591","post","type-post","status-publish","format-standard","hentry","category-adherence","category-all-topics","category-prep"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/26591","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=26591"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/26591\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=26591"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=26591"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=26591"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}