Thank you for your question.<\/p>\n
Despite there only being a small amount of the X4 tropic virus, if you suppress all the R5 tropic virus using maraviroc then the virus would just entirely shift to X4.<\/p>\n
An alternative would be, based on a very careful review of resistance history, to stop T-20 and monitor the viral load weekly. At the first sign of a viral rebound (an increase in your viral load), you could restart with T-20 and likely resuppress the virus again but these may be some complications.<\/p>\n
The potency of raltegravir, darunavir and etravirine together may be sufficient to maintain viral suppression once you stop the T-20.<\/p>\n
Given the important quality of life issues you were explaining with regards to the difficulty of administration of T-20, this will make a big impact on your life. It should also be safe and effective.<\/p>\n","protected":false},"excerpt":{"rendered":"
I am currently on darunavir, raltegravir, norvir, etravirine, epivir and T20. I have been on treatment since 1996 and have resistance to most ARVs. Due to injection site reactions, I am considering substituting maraviroc for T20 and would like advice on whether this is a good idea or not.<\/p>\n
My blood has been sent for a tropism test in the UK which shows I have mostly R5 tropic virus and have a small amount of X4 tropic virus.<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,35,38],"tags":[],"class_list":["post-2683","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-resistance","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/2683","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=2683"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/2683\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=2683"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=2683"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=2683"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}