{"id":26885,"date":"2026-10-13T11:41:59","date_gmt":"2026-10-13T11:41:59","guid":{"rendered":"https:\/\/i-base.info\/qa\/?p=26885"},"modified":"2026-10-15T14:27:04","modified_gmt":"2026-10-15T14:27:04","slug":"what-happens-with-my-weight-if-i-keep-on-taking-tld-volutrip","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/26885","title":{"rendered":"Will my weight change if I am taking HIV meds called Volutrip (TLD)?"},"content":{"rendered":"<p>Hi there<\/p>\n<p>Thanks, average weight increased in some studies but that this might be a normal recovery from HIV. Also, average changes doesn&#8217;t mean that everyone would be, affected. Either way, HIV clinics should monitor everyone&#8217;s weight before and when on ART. Diet and exercise might help reverse fat gain\/.<\/p>\n<p><a href=\"https:\/\/i-base.info\/guides\/12423\">Volutrip<\/a> is one of many <a href=\"https:\/\/i-base.info\/guides\/12423\">generic<\/a> forms of <strong><a href=\"https:\/\/i-base.info\/guides\/14970\">TLD<\/a><\/strong>.<\/p>\n<p>This contains <strong>t<\/strong>enofovir DF +<strong> l<\/strong>amivudine +<strong> d<\/strong>olutegravir (ie TLD).<\/p>\n<p>Some studies, including in South Africa, reported weight gain with TLD that was higher in African women than in African men.<\/p>\n<p>Although people gained less weight using a combination with efavirenz (instead of dolutegravir), the difference was because efavirenz and and tenofovir limits weight gain.<\/p>\n<p>Other studies reported that the weight increases with TLD were part of returning to better health &#8211; and that the weight gain brought people up to the South African average weight.<\/p>\n<p>As this is a complicated issue I would need more details to give a more individual answer.<\/p>\n<p>For example:<\/p>\n<ul>\n<li>Are you already taking Volutrip? If yes, for how long.<\/li>\n<li>Was this your first combination or did you switch from something else? This is because previous drugs can affect the changes.<\/li>\n<li>Do you know your rough CD4 count history and viral load? This is because weight gain is more likely if someone start with a low CD4 or high viral load &#8211; ie as a return to better health.<\/li>\n<li>It also helps to know your age, sex, weight and height and how this has changed over time. Women might gain more weight than men.<\/li>\n<li>What has your doctor said about the changes? Have you talked to the clinic and are they monitoring this.<\/li>\n<\/ul>\n<p>The last of these is important because everyone should be weighed before starting ART. They should also be weighed every 6\u201312 months on treatment to record any changes.<\/p>\n<p>Unfortunately the isn&#8217;t an easy way to reduce weight,<\/p>\n<p>Usually this involves a careful programme of diet and exercise.<\/p>\n<p>Sometimes GLP-1 RA drugs (such as semaglutide or tirzepatide) that are proven to help lose weight are also used.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hi there, I am HIV positive and live in South Africa. Will Volutrip affect my weight?<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,7,13,38,49],"tags":[],"class_list":["post-26885","post","type-post","status-publish","format-standard","hentry","category-adherence","category-all-topics","category-complications-and-coinfections","category-side-effects","category-south-africa"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/26885","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=26885"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/26885\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=26885"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=26885"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=26885"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}