This is an area that is only starting to get more attention in HV research.<\/p>\n
Certainly not everyone using PIs with get diabetes, and a very recent study showed that the risk may be linked to other HIV drugs. A history of high blood sugar is likely to increase any risk and highlights the importance of looking at modifiable lifestyle changes.<\/p>\n
The MACS cohort in the US suggested that the risk for developing diabetes mellitus (DM) is higher in HIV positive people on treatment than HIV negative people.<\/p>\n
This was roughly a 4-fold higher risk: over 4 years new DM occurred in 24 of 229 (10%) HIV positive compared with 10 of 361 (3%) of HIV negative men. Age and Body Mass Index (BMI), which both increase risk of diabetes were both adjusted for in the study. Lipodystrophy is also associated with DM.<\/p>\n
However, a much larger analysis from the D:A:D study (that includes over 33,000 patients mainly from European cohorts) reported different results at a conference in Glasgow this week.<\/p>\n
The D:A:D study found 2.8% patients had diabetes when they entered the study, and that 745 new cases occurred over 130,000 patient-years of follow up – giving an incidence of 5.7 cases per 1000 patient years,<\/p>\n
Interstingly, the only drug significantly linked to the risk of DM was d4T (roughly 8-fold higher risk). Smaller effects were seen for both AZT and ddI. However, both ritonavir and nevirapine showed a slightly reduced (ie beneficial) effect.<\/p>\n
However, the study also cautioned that diabetes as serious endpoint, could be missing lower glade changes in reduced glucose tolerance related to PIs (that can be a risk factor for progressing to diabetes in the future).<\/p>\n
Many factors associated with higher risk of diabetes and high blood sugar\/reduced glucose tolerance, are modifiable. including healthier diet, stopping smoking and increasing exercise. Higher non-modifiable risk factors – a family history of diabetes, male sex, and getting older, makes looking at these other factors is much more important.<\/p>\n
Diabetes is a serious illnesses and increases your risk for future heart disease, so reducing risks is good advice.<\/p>\n","protected":false},"excerpt":{"rendered":"
I have read lots of information on drug side effects, which I find that PIs and some other drugs will highly increase blood sugar and then cause diabetes. <\/p>\n
I cannot find the statistics of the rate of the patients who will get diabetes by taking the drugs. So I am wondering, does that everyone take PIs will cause diabetes in the end? <\/p>\n
Or only those who have the history of high blood sugar or diabetes are more likely to cause or worse it? or This is just a not common side effect? <\/p>\n
Thank you for your time.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,38],"tags":[],"class_list":["post-28","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/28","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=28"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/28\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=28"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=28"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=28"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}