{"id":3357,"date":"2010-11-25T02:58:08","date_gmt":"2010-11-25T02:58:08","guid":{"rendered":"http:\/\/i-base.info\/qa\/3357"},"modified":"2010-11-25T02:58:08","modified_gmt":"2010-11-25T02:58:08","slug":"is-it-nrtis-or-nnrtis-that-need-to-be-transformed","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/3357","title":{"rendered":"Is it NRTIs or NNRTIs that need to be transformed?"},"content":{"rendered":"<p>I think you are asking about a process called phosphorylation.<\/p>\n<p>This is where NRTIs (Nucleoside Reverse Transcriptase Inhibitors, also called &#8216;nukes&#8217;) go through a process of being changed into the active part of the drug that will block HIV replication.<\/p>\n<p>Nucleosides are changed (or metabolised) three times inside the cell to the monophosphate, then diphosphate, then triphosphate (acitve) from of the drug.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Is it NNRTIs or NRTIs that need to be chemically transformed before is active and what is the enzyme to carry out this transformation?<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7],"tags":[],"class_list":["post-3357","post","type-post","status-publish","format-standard","hentry","category-all-topics"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/3357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=3357"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/3357\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=3357"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=3357"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=3357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}