{"id":4056,"date":"2011-05-27T14:18:17","date_gmt":"2011-05-27T14:18:17","guid":{"rendered":"http:\/\/i-base.info\/qa\/?p=4056"},"modified":"2011-05-27T14:18:17","modified_gmt":"2011-05-27T14:18:17","slug":"what-causes-sustiva-to-have-effects-on-the-brain","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/4056","title":{"rendered":"What causes Sustiva to have effects on the brain?"},"content":{"rendered":"<p>Thank you for your question.<\/p>\n<p>Not very much is known about how exactly efavirenz works in the brain to cause the side effects you describe and why some people have these symptoms and others don&#8217;t. It is a very difficult area to research due to the brain and CFS being so hard to access and test for drug levels etc.<\/p>\n<p>There is also little known about toxicity and whether or not the brain is damaged by the drugs. <a href=\"http:\/\/www.natap.org\/2010\/CROI\/croi_56.htm\">This study <\/a>was done recently found that some concentrations of ARVs can carry some risk of neuronal damage.<\/p>\n<p>If you are having these side effects then it is very important that you talk to your doctor about changing treatment. For more information please ready this <a href=\"https:\/\/i-base.info\/qa\/611\">similar question<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>I have been on Sustiva for a while now and shortly after taking it, I always get a feeling of being very &#8216;high&#8217; and extremely drunk, to the point where I cannot stand or talk properly.<\/p>\n<p>I&#8217;ve read about other people refering to the drug similar to being &#8216;stoned&#8217; or on acid but as I have never experienced either of these, I was just wondering what exactly causes Sustiva to have these effects on the brain?<\/p>\n<p>I understand Sustiva affects the CNS but what exactly does it do to make me feel so drunk, surely this isn&#8217;t good for the brain.<\/p>\n<p>Thanks in anticipation.<\/p>\n","protected":false},"author":5,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,10,38],"tags":[],"class_list":["post-4056","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-changing-treatment","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/4056","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=4056"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/4056\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=4056"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=4056"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=4056"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}