{"id":4239,"date":"2011-06-21T09:20:48","date_gmt":"2011-06-21T09:20:48","guid":{"rendered":"http:\/\/i-base.info\/qa\/?p=4239"},"modified":"2011-06-21T09:20:48","modified_gmt":"2011-06-21T09:20:48","slug":"what-is-the-risk-of-resistance-from-a-late-dose-of-atripla","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/4239","title":{"rendered":"What is the risk of resistance from a late dose of Atripla?"},"content":{"rendered":"

It is good to get into the habit of aiming for the same time but one late dose over three months will not have done you any harm.<\/p>\n

The three drugs in Atripla probably give you a good window period of at least two hours in which to take them without any problems. When starting out, for the first three months or until you viral load is undetectable, if is always good to aim for the same time.<\/p>\n

Once your viral load has been undetectable for several months, even missing an odd dose completely, is unlikely to cause resistance.<\/p>\n

A study called FOTO<\/a> (Five On Two Off) followed a small group of people who were taking Atripla and who had undetectable viral load. For the next year they took Atripla only on week days (five-on) and not at weekend (two-off). Viral load stayed undetectable (less than 50 copies\/mL) throughout this study.<\/p>\n

I’m not suggesting missing doses routinely or copying the study, but the results should take some of the stress out of an occasional accident.<\/p>\n

This study was specific to the three drugs in Atripla, which all achieve high concentrations that generally leave the body slowly. Many people in this study would have had active drug levels even when they were not taking the weekend doses.<\/p>\n

You are getting a great response from treatment, and your next results will probably be undetectable.<\/p>\n

See also\u00a0this Q&A<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Hi I’ve been on Atripla since early April 2011.<\/p>\n

My last three viral load and CD4 results were: VL 277,750; CD4 468 (March); VL 3,458; CD4 550 (April): VL 1,060; CD4 700 (May).<\/p>\n

The problem is I was late taking my dose last Wednesday. I was one hour and 45 minutes late. A stupid mistake caused becasue i was in a theatre & had to switch off my alarm. I completely forgot but took the pill straight away I remembered.<\/p>\n

This is the only time I have been late but I am worried about resistance developing becasue I am not quite undetectable yet.<\/p>\n

Please let me know what to expect and the chances of resistance. And how soon I will know if resistance has manifested.<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,7,35],"tags":[],"class_list":["post-4239","post","type-post","status-publish","format-standard","hentry","category-adherence","category-all-topics","category-resistance"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/4239","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=4239"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/4239\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=4239"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=4239"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=4239"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}