{"id":4387,"date":"2011-07-15T22:02:54","date_gmt":"2011-07-15T22:02:54","guid":{"rendered":"http:\/\/i-base.info\/qa\/?p=4387"},"modified":"2016-08-31T22:47:30","modified_gmt":"2016-08-31T22:47:30","slug":"will-i-have-resistance-from-these-missed-doses-of-atripla","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/4387","title":{"rendered":"Will I have resistance from these missed doses of Atripla?"},"content":{"rendered":"<p>Hi<\/p>\n<p>Please see <a href=\"https:\/\/i-base.info\/qa\/4239\">this similar Q&amp;A<\/a>. The reference and link to the FOTO study is an example of why you may still be okay.<\/p>\n<p>Because the three drugs in Atripla take a long time to leave your body, if you miss three separate doses each month, the drugs levels may still keep the virus suppressed without developing resistance.<\/p>\n<p>If you are missing three consecutive days in in a row &#8211; then your risk is more serious, and trying to get back to better adherence is important. At the end of the third day you would be a risk of resistance much more easily. If your viral load rebounded after these longer breaks, then it is likely to be with resistance virus.<\/p>\n<p>Also, think about why your feeling changed. Accepting your diagnosis and yoru successful response to treatment, means you can think about a normal lifespan again. In a funny way that can also be strange after the shock of a diagnosis where you think a lot about mortality.<\/p>\n<p>Because of the way you are worrying, I&#8217;m sure you will be able to get this back under control again. It is good that you feel confident to have these open discussions with your pharmacist.<\/p>\n<p>Cohen C et al. The FOTO study: The 48 week extension to assess durability of the strategy of taking efavirenz, tenofovir and emtricitabine Five days On, Two days Off (FOTO) each week in virologically suppressed patients. 5th IAS Conference, 2009. Abstract MOPEB063.<br \/>\n<a href=\"http:\/\/library.iasociety.org\/AbstractView.aspx?confID=2009&amp;abstractId=3046\">http:\/\/library.iasociety.org\/AbstractView.aspx?confID=2009&amp;abstractId=3046<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hi,<\/p>\n<p>When I was first diagnosed HIV positive, I suffered from anxiety and was neurotic about my regime. Since I have had therapy and become more accepting of my HIV, I have become more relaxed and careless about my meds. I have been missing a dose of Atripla about three times a month on average.<\/p>\n<p>Now, I am currently trying hard to improve my adherance, but I am worried that I have already developed resistance.<\/p>\n<p>My viral load was undetectable the last time I got my blood results. My pharmasist says I will most likely have a rise in my viral load count, but that it will not necessarily mean I have developed resistance. I find this confusing as I thought a rise in my viral load count would mean I have developed resistance.<\/p>\n<p>Do you think I still have a chance to change my adherance before it&#8217;s too late to continue with taking Atripla?<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,9,10,35],"tags":[],"class_list":["post-4387","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-cd4-and-viral-load","category-changing-treatment","category-resistance"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/4387","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=4387"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/4387\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=4387"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=4387"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=4387"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}