{"id":488,"date":"2008-06-09T12:20:59","date_gmt":"2008-06-09T11:20:59","guid":{"rendered":"http:\/\/www.i-base.info\/qa\/?p=488"},"modified":"2021-11-22T12:18:24","modified_gmt":"2021-11-22T12:18:24","slug":"how-often-can-i-miss-a-dose","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/488","title":{"rendered":"How often can I miss a dose?"},"content":{"rendered":"<p>I have a very traditional opinion and will have to say that you cannot miss doses safely.<\/p>\n<p>The thing is that HIV does not mutate selectively, it does it randomly. Hense missing a dose is like a Russian roulette. During the period when the virus can replicate (as there is not enough medication to supress it in your body), it can mutate in such a way, that it becomes resistant to the medication, but it also can mutate in a way that it does not become resistant.<\/p>\n<p>Hence every missed dose is a potential resistance provoker and it is more true with the non-nucleoside reverse transcriptase inhibitors (Sustiva and Viramune) than with the protease inhibitors.<\/p>\n<p>At the same time, as I mentioned before, not every missed dose will by default lead to resistance, but, again, less is better.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Hi, I have been on Sustiva\/Truvada for 7 months and only missed 1 dose.<br \/>\nIn your opinion how often could you safeley miss a dose? Not intending to purposely miss doses just a question really. Thanks!<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,7,35],"tags":[],"class_list":["post-488","post","type-post","status-publish","format-standard","hentry","category-adherence","category-all-topics","category-resistance"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/488","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=488"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/488\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=488"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=488"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=488"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}