{"id":5450,"date":"2011-12-21T17:55:19","date_gmt":"2011-12-21T17:55:19","guid":{"rendered":"http:\/\/i-base.info\/qa\/?p=5450"},"modified":"2016-08-31T22:44:19","modified_gmt":"2016-08-31T22:44:19","slug":"i-missed-four-doses-of-atripla-will-this-cause-me-health-problems","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/5450","title":{"rendered":"I missed four doses of atripla. will this cause me health problems?"},"content":{"rendered":"<p>Can I ask what happened this time and whether this is likely to happen again?<\/p>\n<p>This is because, the chance of developing resistance becomes a concern if you miss Atripla doses regularly.<\/p>\n<p>The three drugs in Atripla (efavirenz, FTC and tenofovir) all have good concentrations at the end of each 24-hour dose to cover you for a few hours either way.<\/p>\n<p>This was shown in a study called FOTO which followed people taking Atripla on weekdays and missing the two days at the weekend. After one year everyone still had a viral load that was undetectable (less than 50 copies\/mL).<\/p>\n<p>Please follow this <a href=\"http:\/\/library.iasociety.org\/AbstractView.aspx?confID=2009&amp;abstractId=3046\">link<\/a> for more information on the FOTO study.<\/p>\n<p>No treatment guidelines recommend following the FOTO strategy, but it is a good example of how an occasional missed dose of Atripla is unlikely to do any harm.<\/p>\n<p>Having said that though,\u00a0 adhering to your medication is extremely important. Please follow this <a href=\"https:\/\/i-base.info\/guides\/starting\/adherence\">link<\/a> for more information on the importance of adherence.<\/p>\n<p>As you missed 4 doses of your medication, it is recommended that you discuss this further with your doctor. This is important especially if you feel that you may be likely to miss as many doses again in the future.<\/p>\n<p>Please also follow this <a href=\"https:\/\/i-base.info\/qa\/4387\">link<\/a> where a similar question has been answered in more detail.<\/p>\n<p>FOTO STUDY: Cohen C et al. The FOTO study: The 48 week extension to assess durability of the strategy of taking efavirenz, tenofovir and emtricitabine Five days On, Two days Off (FOTO) each week in virologically suppressed patients.\u00a0<span id=\"ctl00_cphCenter_ctl02_lbConference\" class=\"conferences\">IAS 2009, Cape Town.\u00a0<\/span>Abstract\u00a0<span id=\"ctl00_cphCenter_ctl02_lbAbstractNumber\" class=\"abstractNumber\">MOPEB063.<br \/>\n<\/span><a href=\"http:\/\/library.iasociety.org\/AbstractView.aspx?confID=2009&amp;abstractId=3046\">http:\/\/library.iasociety.org\/AbstractView.aspx?confID=2009&amp;abstractId=3046<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>I last took my Atripla 4 days ago due to circumstances beyond my control.<\/p>\n<p>Should I expect the worst with my health.<\/p>\n<p>I am so confused  right now.<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,7],"tags":[],"class_list":["post-5450","post","type-post","status-publish","format-standard","hentry","category-adherence","category-all-topics"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/5450","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=5450"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/5450\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=5450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=5450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=5450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}