{"id":6728,"date":"2012-04-23T13:43:03","date_gmt":"2012-04-23T13:43:03","guid":{"rendered":"http:\/\/i-base.info\/qa\/?p=6728"},"modified":"2012-04-23T13:43:03","modified_gmt":"2012-04-23T13:43:03","slug":"where-can-i-find-studies-on-reasons-for-cd4-count-changes","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/6728","title":{"rendered":"Where can I find studies on reasons for CD4 count changes?"},"content":{"rendered":"<p>Thank you for your question.<\/p>\n<p>A number of studies have looked at this question\u00a0 and confirm that  CD4 counts are not accurate fixed results. They fluctuate throughout the day for example lower readings in the morning and higher later in the day etc. If you were to have a test every week, they would probably change even more. For example, your CD4 count is generally 50 cells higher in the morning compared to at night, and can be affected in a similar superficial way by diet and excercise and other infections.<\/p>\n<p>Below, please find a couple of studies looking at this question.<\/p>\n<ul>\n<li>The first one is a key study by J Malone and others. This study  has also  been quoted in a number of other studies. It looked at <a href=\"http:\/\/journals.lww.com\/jaids\/Abstract\/1990\/02000\/Sources_of_Variability_in_Repeated_T_Helper.9.aspx\">the reasons for and extent of CD4 count variations.<\/a><\/li>\n<li>The second study by GH Mientjes and others, looked at <a href=\"http:\/\/journals.lww.com\/aidsonline\/Abstract\/1992\/11000\/Large_diurnal_variation_in_CD4_cell_count_and.5.aspx\">changes in CD4 cell count and T-function among drug users.<\/a> <a href=\"http:\/\/www.virusmyth.com\/aids\/hiv\/milowcd4.htm\"><br \/>\n<\/a><\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>In lots of questions here you talk about the variation in CD4 count and that they change during the day and can be affected by diet and excercise. What are the studies that show this so I can read a bit more about this.<\/p>\n<p>Thanks for great site BTW.<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,9],"tags":[],"class_list":["post-6728","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-cd4-and-viral-load"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/6728","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=6728"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/6728\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=6728"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=6728"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=6728"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}