{"id":6906,"date":"2012-05-21T16:03:26","date_gmt":"2012-05-21T16:03:26","guid":{"rendered":"http:\/\/i-base.info\/qa\/?p=6906"},"modified":"2012-05-21T16:03:26","modified_gmt":"2012-05-21T16:03:26","slug":"why-does-truvada-atripla-have-different-food-restrictions","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/6906","title":{"rendered":"Why does Truvada &amp; Atripla have different food restrictions?"},"content":{"rendered":"<p>Some ARVs (antiretroviral treatments for HIV), need to be taken with food. This is so that their concentration reaches the levels necessary to suppress the virus.<\/p>\n<p>Recommendations for taking Truvada differ in for Europe and the US. Although in the US you can take Truvada with or without food, in Europe, the recommendation is still to take with food. This difference comes because the food interaction (food increases the levels of tenofovir by 30%),\u00a0 was only discovered after the main trials were well underway. US and European\u00a0 regulatory agencies interpreted the results differently. Please follow this <a href=\"https:\/\/i-base.info\/qa\/707\">link to an earlier question where this has been answered in more detail.<\/a><\/p>\n<p>As regards Atripla, when the drug instructions say take Atripla on an empty stomach, it does not mean that you have to feel physically empty or hungry. That is why the recommendation is to take your medication after about 2 hours without eating. A cup of tea and a biscuit an hour before you take your medication should be fine.<\/p>\n<p>One of the reasons they recommend taking it on an empty stomach\u00a0 is because a high fat meal can increase the drug levels of efavirenz to 60%. Efavirenz is one of the drugs contained in Atripla).Nearly all other foods are fine, just leave a couple of hours when the meal is high fat.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Why does Truvada need to be taken with or after food and Atripla when the stomach is empty or two hours after food or one hour before?<\/p>\n<p>They both contain the same drugs emtricitabine and tenofovir, so does Truvada really need to be taken with food at all? It would make my life easier if it didn&#8217;t.<\/p>\n","protected":false},"author":9,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[5,7],"tags":[],"class_list":["post-6906","post","type-post","status-publish","format-standard","hentry","category-adherence","category-all-topics"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/6906","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/9"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=6906"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/6906\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=6906"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=6906"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=6906"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}