{"id":733,"date":"2008-12-22T14:12:16","date_gmt":"2008-12-22T13:12:16","guid":{"rendered":"http:\/\/www.i-base.info\/qa\/?p=733"},"modified":"2021-11-22T12:17:25","modified_gmt":"2021-11-22T12:17:25","slug":"how-many-combinations-are-there-before-salvage-therapy","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/733","title":{"rendered":"How many combinations are there before salvage therapy?"},"content":{"rendered":"<p>You are right. If you get resistance to 3 or 4 combinations your options are very limited. You then have to wait for new drugs.<\/p>\n<p>Although there are over 20 drugs, getting resistance to one drug in a class, usually results in resistance to other drugs in the same class.<\/p>\n<p>However, you are only likely to get resistance if you miss doses of your meds. This is why near-perfect adherence is important.<\/p>\n<p>Luckily, most people do well on their first combination and less than 5% people in the UK are resistance to all drugs from the nukes, NNRTI and PI classes. Getting undetectable on any combination can mean you can use that combination for years &#8211; in theory over 10 or 20 years &#8211; so long as you are adherent.<\/p>\n<p>The <a href=\"http:\/\/www.i-base.info\/guides\/changing\/index.html\">i-Base guide to Changing Treatment<\/a> goes into detail on all these subjects.<\/p>\n<p>If you&#8217;d like a free print copy posted to you please use <a href=\"http:\/\/www.i-base.info\/forms\/order.php?changing=true\">this link<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>After 1st, 2nd, &amp; 3rd line treatment, is it the end of the road?<\/p>\n<p>Firstly let me thank you for your website and the hard work and effort that goes into it.<\/p>\n<p>I am very confused about how many treatment options we have as patients. I understand that there are around 21 individual drugs, but how many combinations are there? I have read that we only have 1st, 2nd, and 3rd line therapy, before we are classified as being on salvage therapy. So effectively, we only get 3 chances, or 3 combinations, and then your hanging by a thread. So hypothetically speaking if you became resistant to your first 3 combinations fairly quickly, then its nearly the end of the road.<\/p>\n<p>So how can the reports say we have a near to normal life expectancy, when we only get 3 or 4 combinations and then its pretty much game over?<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,10,35],"tags":[],"class_list":["post-733","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-changing-treatment","category-resistance"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/733","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=733"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/733\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=733"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=733"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=733"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}