{"id":812,"date":"2009-04-20T01:01:41","date_gmt":"2009-04-20T00:01:41","guid":{"rendered":"http:\/\/www.i-base.info\/qa\/?p=812"},"modified":"2014-02-04T16:31:22","modified_gmt":"2014-02-04T16:31:22","slug":"do-the-terms-rare-and-common-have-a-specific-meaning-when-discussing-side-effects","status":"publish","type":"post","link":"https:\/\/i-base.info\/qa\/812","title":{"rendered":"How are the words &#8216;rare&#8217; and &#8216;common&#8217; defined for side effects?"},"content":{"rendered":"<p>The <a href=\"http:\/\/www.emea.europa.eu\/\">EMA<\/a> (the European drug regulatory agency) has very specific definitions for words relating to frequency of side effects.<\/p>\n<p>This is a good question because the words are often used wrongly.<\/p>\n<p>This is shown in the table below: ie<\/p>\n<ul>\n<li><strong>Very common<\/strong> affects more than 1 in 10 people &#8211; ie the risk is <strong>10% or higher<\/strong><\/li>\n<li><strong>Common<\/strong> affects between 1 in 100 and 1 in 10 people &#8211; ie risk is <strong>1% to 10%<\/strong><\/li>\n<li><strong>Uncommon<\/strong>\u00a0affects\u00a0between 1 in 1,000 and 1 in 100 people\u00a0&#8211; ie risk is <strong>0.1% to 1%<\/strong><\/li>\n<li><strong>Rare<\/strong> affects\u00a0between 1 in 10,000 and 1 in 1,000 people\u00a0&#8211; ie risk is\u00a0<strong>0.01% to 0.1%<\/strong><\/li>\n<li><strong>Very rare<\/strong> affects less than 1 in 10,000 people\u00a0&#8211; ie risk is\u00a0<strong>less than 0.01% <\/strong>(This includes isolated reports, or where the absolute risk is not known or can&#8217;t be quantified. For example, if identified through post-marketing safety surveillance and the frequency cannot be estimated from the available data).<\/li>\n<\/ul>\n<table border=\"0\">\n<tbody>\n<tr>\n<td><strong>Term<\/strong><\/td>\n<td><strong>Numerical rate<\/strong><\/td>\n<td><strong>Percentage rate<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong><\/strong><strong>Very common<\/strong><\/td>\n<td><strong>More than 1 in 10<\/strong><\/td>\n<td><strong><\/strong><strong>10% or higher<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Common<\/strong><\/td>\n<td><strong>1 in 10 \u2013 1 in 100<\/strong><\/td>\n<td><strong><\/strong><strong><\/strong><strong>10% &#8211; 1%\u00a0<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Uncommon<\/strong><\/td>\n<td><strong>1 in 100 \u2013 1 in 1000<\/strong><\/td>\n<td><strong><\/strong><strong>0.1% to 1%<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Rare<\/strong><\/td>\n<td><strong>1 in 1000 \u2013 1 in 10,000<\/strong><\/td>\n<td><strong>0.01% to 0.1%<\/strong><\/td>\n<\/tr>\n<tr>\n<td><strong>Very rare<\/strong><\/td>\n<td><strong>Less than 1 in 10,000<\/strong><\/td>\n<td><strong>Less than \u00a00.01%<\/strong><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>The EMA (the European drug regulatory agency) has very specific definitions for words relating to frequency of side effects. This is a good question because the words are often used wrongly. This is shown in the table below: ie Very &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[7,38],"tags":[],"class_list":["post-812","post","type-post","status-publish","format-standard","hentry","category-all-topics","category-side-effects"],"_links":{"self":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/812","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/comments?post=812"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/posts\/812\/revisions"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/media?parent=812"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/categories?post=812"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/i-base.info\/qa\/wp-json\/wp\/v2\/tags?post=812"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}