{"id":1330,"date":"2023-01-01T12:00:08","date_gmt":"2023-01-01T12:00:08","guid":{"rendered":"http:\/\/i-base.info\/ttfa\/?page_id=1330"},"modified":"2023-01-23T20:54:21","modified_gmt":"2023-01-23T20:54:21","slug":"appendix-6-stanford-drug-resistance-database-online-tables","status":"publish","type":"page","link":"https:\/\/i-base.info\/ttfa\/hiv-and-drug-resistance\/appendix-6-stanford-drug-resistance-database-online-tables\/","title":{"rendered":"9.  Appendix 6: Stanford Drug Resistance Database online tables"},"content":{"rendered":"<p><strong>The Stanford Drug Resistance Database is one of several online research resources that contain a vast amount of technical information about drug resistance.<\/strong><\/p>\n<p>It includes links to each drug family (<em>drug resistance mutation tables<\/em>) and the related mutations and individual pages for each HIV drug (<em>antiretroviral drug summaries<\/em>).<\/p>\n<p><a href=\"http:\/\/hivdb.stanford.edu\/DR\/\">http:\/\/hivdb.stanford.edu<\/a><\/p>\n<p>The tables are summarised as<a href=\"https:\/\/cms.hivdb.org\/prod\/downloads\/resistance-mutation-handout\/resistance-mutation-handout.pdf\" target=\"_blank\" rel=\"noopener\"> a single page<\/a>. (October 2022).<\/p>\n<p>Notes and comments on mutations are organised by drug class.<\/p>\n<ul>\n<li><a href=\"https:\/\/hivdb.stanford.edu\/dr-summary\/resistance-notes\/NRTI\/\" rel=\"noopener\">NRTIs<\/a><\/li>\n<li><a href=\"https:\/\/hivdb.stanford.edu\/dr-summary\/resistance-notes\/NNRTI\/\" rel=\"noopener\">NNRTIs<\/a><\/li>\n<li><a href=\"https:\/\/hivdb.stanford.edu\/dr-summary\/resistance-notes\/PI\/\" rel=\"noopener\">PIs<\/a><\/li>\n<li><a href=\"https:\/\/hivdb.stanford.edu\/dr-summary\/resistance-notes\/INSTI\/\" rel=\"noopener\">Integrase inhibitors (INSTIs)<\/a><\/li>\n<\/ul>\n<p>These tables are complicated but they are explained in notes for each mutation. (See Table 4).<\/p>\n<p><strong>Table 4: Integrase inhibitor (INSTI) resistance mutations (Stanford database, 2022)<\/strong><\/p>\n\n<p><a href=\"https:\/\/i-base.info\/ttfa\/wp-content\/uploads\/2023\/01\/NNRTI-Stanfod-table-2022.png\"><img loading=\"lazy\" decoding=\"async\" class=\"alignnone wp-image-1873 size-full\" src=\"https:\/\/i-base.info\/ttfa\/wp-content\/uploads\/2023\/01\/NNRTI-Stanfod-table-2022.png\" alt=\"\" width=\"2773\" height=\"705\" srcset=\"https:\/\/i-base.info\/ttfa\/wp-content\/uploads\/2023\/01\/NNRTI-Stanfod-table-2022.png 2773w, https:\/\/i-base.info\/ttfa\/wp-content\/uploads\/2023\/01\/NNRTI-Stanfod-table-2022-300x76.png 300w, https:\/\/i-base.info\/ttfa\/wp-content\/uploads\/2023\/01\/NNRTI-Stanfod-table-2022-1024x260.png 1024w, https:\/\/i-base.info\/ttfa\/wp-content\/uploads\/2023\/01\/NNRTI-Stanfod-table-2022-768x195.png 768w, https:\/\/i-base.info\/ttfa\/wp-content\/uploads\/2023\/01\/NNRTI-Stanfod-table-2022-1536x391.png 1536w, https:\/\/i-base.info\/ttfa\/wp-content\/uploads\/2023\/01\/NNRTI-Stanfod-table-2022-2048x521.png 2048w\" sizes=\"auto, (max-width: 2773px) 100vw, 2773px\" \/><\/a><\/p>\n<p>The\u00a0<strong>consensus sequence<\/strong>\u00a0means wild-type non-resistant virus. The letters in the <em>Consensus<\/em> row refer to the amino acids that should be at those junctions (codons).<\/p>\n<p>The line of numbers above the &#8216;Cons&#8217; row are the positions or junctions where important changes occur.<\/p>\n<p>Each of these junctions (called a codon) in integrase is linked to resistance to different integrase inhibitors.<\/p>\n<p>The letter in the main body of the table shows the amino acid changes at each codon, Letters in <strong>bold<\/strong> show that this is an important mutation in reducing how well that drug will work. Letters in <strong>red<\/strong> indicate high levels of resistance that stop the drug from working at all.<\/p>\n<p>Each row is for a different integrase inhibitor. If codon 118 changes from G to R (ie mutation G118R), then cabotegravir, raltegravir and elvitegravir will no longer work and dolutegravir and bictegravir will be less effective.<\/p>\n<p>The detailed\u00a0comments on G118R below\u00a0include more detail about this mutation mainly developing in people who are on dolutegravir, and on levels of resistance for each INSTI.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Stanford Drug Resistance Database is one of several online research resources that contain a vast amount of technical information about drug resistance. It includes links to each drug family (drug resistance mutation tables) and the related mutations and individual &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":1277,"menu_order":11,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1330","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages\/1330","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/comments?post=1330"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages\/1330\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages\/1277"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/media?parent=1330"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}