{"id":1351,"date":"2023-01-01T12:00:11","date_gmt":"2023-01-01T12:00:11","guid":{"rendered":"http:\/\/i-base.info\/ttfa\/?page_id=1351"},"modified":"2023-01-23T18:56:55","modified_gmt":"2023-01-23T18:56:55","slug":"appendix-9-examples-of-resistance-test-reports","status":"publish","type":"page","link":"https:\/\/i-base.info\/ttfa\/hiv-and-drug-resistance\/appendix-9-examples-of-resistance-test-reports\/","title":{"rendered":"9. Appendix 9: Examples of resistance test reports"},"content":{"rendered":"

Sample of genotype test<\/h2>\n

Most resistance tests in the UK use the Stanford database (or similar resource) to generate a resistance report.<\/strong><\/p>\n

The list of mutations is put into an online resource that generates the report. Personal identification information is also included in real reports.<\/p>\n

The sample below shows the section of a sample report for nukes and NNRTIs.<\/p>\n

Example of resistance report from Stanford database<\/strong><\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

\"\"<\/p>\n

Source: Stanford database \u2013 For a full explanation see information on the Stanford website<\/a>.<\/p>\n

Sample virtual phenotype test<\/h2>\n

The second example is from the virtual phenotype from Virco called VircoTYPE.<\/strong><\/p>\n

Please note that this test was withdrawn in November 2013 because of low use.<\/em><\/p>\n

It is included here as an example of how phenotype results are linked to genotypic mutations – and partly for historical reasons.<\/p>\n

The mutations that were found in the sample are listed above each drug class, ie for nukes (NRTIs), NNRTIs and PIs.<\/p>\n

The fold change reported for each drug – ie 8.7 for zidovudine (AZT) in this first example – ie the predictated phenotypic.<\/p>\n

The cut-offs in the next two columns refer to the lower (less than 20% imapct) and upper (more than 80% impact) ranges.<\/p>\n

The next column shows the result of the analysis. If the fold change is below the lower cut-off the drug is sensitive. If it is between this range the drug is intermediate with a reduced response. If it is above the upper cut-off it is resistant.<\/p>\n

The second page of a Virco report includes mnore detailed table showing the predicted phenotypic results more graphically.<\/p>\n

Confidence intervals are included for each fold change result which gives you an idea of how many samples in the Virco database had similar mutations to your sample.<\/p>\n

For an explanation of these reports see the detailed information on the Virco website.<\/p>\n

Virtual Phenotype sample report (Virco) – page 1<\/strong><\/p>\n

\"\"<\/p>\n

Virtual Phenotype sample report (Virco) – page 2<\/strong><\/p>\n

\"\"<\/p>\n

Source: Virco Diagnostics<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"

Sample of genotype test Most resistance tests in the UK use the Stanford database (or similar resource) to generate a resistance report. The list of mutations is put into an online resource that generates the report. Personal identification information is …<\/p>\n","protected":false},"author":5,"featured_media":0,"parent":1277,"menu_order":14,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-1351","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages\/1351","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/users\/5"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/comments?post=1351"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages\/1351\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages\/1277"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/media?parent=1351"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}