{"id":337,"date":"2009-07-22T21:01:57","date_gmt":"2009-07-22T20:01:57","guid":{"rendered":"http:\/\/moomango.co.uk\/ttfa\/?page_id=337"},"modified":"2009-07-22T21:01:57","modified_gmt":"2009-07-22T20:01:57","slug":"tb-and-arv-drug-interactions-summary","status":"publish","type":"page","link":"https:\/\/i-base.info\/ttfa\/learning-resources\/tb-and-arv-drug-interactions-summary\/","title":{"rendered":"TB and ARV drug interactions summary"},"content":{"rendered":"<p><strong>Table: TB drug side effects and interactions<\/strong><\/p>\n<table border=\"0\">\n<tbody>\n<tr>\n<th>Drug<\/th>\n<th>Side effects<\/th>\n<th>Potential drug interactions<\/th>\n<th>Notes<\/th>\n<\/tr>\n<tr>\n<td><strong>ethambutol<\/strong><\/td>\n<td>Rash, joint pain, gut upset, fever, headache, dizziness, eyesight problems.<\/td>\n<td>Antacids.<\/td>\n<td>Check eyesight often.<\/td>\n<\/tr>\n<tr>\n<td><strong>isoniazid<\/strong><\/td>\n<td>Gut upset, loss of appetite, fever, rash, liver problems, peripheral neuropathy.<\/td>\n<td>Phenytoin, antacids, alcohol, steroids.<\/td>\n<td>Take on an empty stomach. Take pyridoxine (vitamin B6) to prevent peripheral neuropathy. Monitor liver function.<\/td>\n<\/tr>\n<tr>\n<td><strong>pyrazinamide<\/strong><\/td>\n<td>Gut upset, fever, rash, joint pain, hepatitis, gout, light sensitivity.<\/td>\n<td>None.<\/td>\n<td>Monitor liver function.<\/td>\n<\/tr>\n<tr>\n<td><strong>rifampicin<\/strong><\/td>\n<td>Gut upset, rash, fever, orange urine\/tears\/saliva, light sensitivity, liver problems, acute renal failure<\/td>\n<td>PIs, NNRTIs, \u2018-azole\u2019 anti-fungal drugs, oral contraceptives, methadone, dapsone.<\/td>\n<td>Take on an empty stomach. Do not use with PIs or nevirapine.<\/td>\n<\/tr>\n<tr>\n<td><strong>rifabutin<\/strong><\/td>\n<td>Gut upset, rash, eye inflammation, blood cell changes, joint pain, orange urine\/tears\/saliva, liver function changes, fever.<\/td>\n<td>PIs, NNRTIs, fluconazole, oral contraceptives, steroids, methadone.<\/td>\n<td>Avoid wearing soft contact lenses as they can become discolored. Avoid nevirapine.<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n<p><strong>Table: Which TB drugs go with different ARVs?<\/strong><\/p>\n<table border=\"0\">\n<tbody>\n<tr>\n<th>ARV<\/th>\n<th>Rifampicin<\/th>\n<th>Rifabutin<\/th>\n<th>Notes<\/th>\n<\/tr>\n<tr>\n<td><strong>nukes<\/strong><\/td>\n<td>Use<\/td>\n<td>Use<\/td>\n<td>no interactions<\/td>\n<\/tr>\n<tr>\n<td><strong>efavirenz<\/strong><\/td>\n<td>Use<\/td>\n<td>Use<\/td>\n<td>rifampicin: efavirenz dose usually 800mg daily \u2013 rifabutin: 450 or 600mg daily or 600mg twice weekly recommended<\/td>\n<\/tr>\n<tr>\n<td><strong>nevirapine<\/strong><\/td>\n<td>Do not use<\/td>\n<td>Do not use<\/td>\n<td>high risk of liver toxicity<\/td>\n<\/tr>\n<tr>\n<td><strong>nelfinavir<\/strong><\/td>\n<td>Do not use<\/td>\n<td>Use<\/td>\n<td>rifabutin: 150mg daily recommended<\/td>\n<\/tr>\n<tr>\n<td><strong>boosted PIs<\/strong><\/td>\n<td>Do not use<\/td>\n<td>Use<\/td>\n<td>rifabutin: 150mg daily or 300mg twice weekly recommended<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"<p>Table: TB drug side effects and interactions Drug Side effects Potential drug interactions Notes ethambutol Rash, joint pain, gut upset, fever, headache, dizziness, eyesight problems. Antacids. Check eyesight often. isoniazid Gut upset, loss of appetite, fever, rash, liver problems, peripheral &hellip;<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":315,"menu_order":8,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-337","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages\/337","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/comments?post=337"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages\/337\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages\/315"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/media?parent=337"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}