Including opiate substitues and alcohol<\/p>\n
Table: ARV and street drug interactions summary Table\u00a0 based on: T Auntonio and A Lin-in Tseng. Interactions Between Recreational Drugs and Anti-retroviral Agents, Annals of Pharmacotherapy. 2000, October, Volume 36.<\/p>\n","protected":false},"excerpt":{"rendered":" Including opiate substitues and alcohol Table: ARV and street drug interactions summary Drug Interaction Significance Recommendation Alcohol None None None Amphetamines Possible prolonged effect or higher concentrations with ARVS especially ritonavir High body temperature, high blood pressure, fast heartbeat, rapid …<\/p>\n","protected":false},"author":2,"featured_media":0,"parent":315,"menu_order":7,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-357","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages\/357","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/comments?post=357"}],"version-history":[{"count":0,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages\/357\/revisions"}],"up":[{"embeddable":true,"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/pages\/315"}],"wp:attachment":[{"href":"https:\/\/i-base.info\/ttfa\/wp-json\/wp\/v2\/media?parent=357"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}
\n<\/strong><\/p>\n\n\n
\n Drug<\/th>\n Interaction<\/th>\n Significance<\/th>\n Recommendation<\/th>\n<\/tr>\n \n Alcohol<\/td>\n None<\/td>\n None<\/td>\n None<\/td>\n<\/tr>\n \n Amphetamines<\/td>\n Possible prolonged effect or higher concentrations with ARVS especially ritonavir<\/td>\n High body temperature, high blood pressure, fast heartbeat, rapid breathing, seizures<\/td>\n Avoid using with ritonavir if possible \u2013 or use less<\/td>\n<\/tr>\n \n Benzodiazepines<\/td>\n Norvir may increase levels<\/td>\n Over-sedation, respiratory depression<\/td>\n Lower benzodiazepine dose if necessary<\/td>\n<\/tr>\n \n Cannabis<\/td>\n None<\/td>\n None<\/td>\n None<\/td>\n<\/tr>\n \n Cocaine<\/td>\n None<\/td>\n None<\/td>\n None<\/td>\n<\/tr>\n \n Ecstasy, MDMA<\/td>\n Possible higher concentrations with ritonavir, other PIs and efavirenz<\/td>\n 1 death reported \u2013 low sodium level in the blood, abnormal heartbeat, fast heartbeat, high body temperature, sweating, seizures, overactive reflexes, tremors, disintegration of muscle fibres.<\/td>\n Avoid using with ritonavir if possible \u2013 or use less \u2013 stay hydrated and avoid alcohol.<\/td>\n<\/tr>\n \n GHB<\/td>\n Possible interaction with ritonavir<\/td>\n 1 case of near-fatal GHB poisoning with ritonavir + saquinavir \u2013 muscle spasms, seizures, slow heart rate, poor breathing, unconsciousness<\/td>\n Caution with ritonavir, other PIs, efavirenz \u2013 be aware of signs of GHB toxicity.<\/td>\n<\/tr>\n \n Heroin, buprenorphine and methadone<\/td>\n Efavirenz and nevirapine: methadone level up to 60% lower.Efavirenz: buprenorphine levels up to 50% lower. Ritonavir: may increase or decrease opiate level. Nelfinavir and Kaletra: reduces level of methadone. Methadone: decreases level of d4T and ddI, doubles level of AZT. Heroin: may be processed faster with PIs and efavirenz.<\/td>\n Lower levels of methadone and heroin may lead to signs of withdrawal. Higher levels of ARVs may increase side effects.<\/td>\n Higher dose of methadone may be needed. Use half the normal dose of AZT. No recommendation for d4T or ddI. Buprenorphine dose not usually changed.<\/td>\n<\/tr>\n \n Ketamine<\/td>\n Possible higher concentrations with ritonavir, nelfinavir and efavirenz<\/td>\n Poor breathing, unconsciousness, hallucinations<\/td>\n Caution with ritonavir, other PIs, efavirenz \u2013 be aware of signs of ketamine toxicity.<\/td>\n<\/tr>\n \n LSD<\/td>\n Possible higher concentrations<\/td>\n Hallucinations, agitation, psychosis, flashbacks<\/td>\n Caution with ritonavir, other PIs, efavirenz \u2013 be aware of signs of LSD toxicity.<\/td>\n<\/tr>\n \n PCP (angel dust)<\/td>\n Possible higher concentrations<\/td>\n High body temperature, high blood pressure, seizures, disintegration of muscle fibres.<\/td>\n Caution with ritonavir, other PIs, efavirenz \u2013 be aware of signs of PCP toxicity.<\/td>\n<\/tr>\n \n Sildenafil (Viagra) and similar drugs<\/td>\n Ritonavir increases level of erectile dysfunction agents<\/td>\n Headache, priapism, palpitations, visual changes, low blood pressure.<\/td>\n Use less (eg 25mg instead of 100mg sildenafil)<\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n