i-base

Pictures and diagrams

Collection of pictures and diagrams for study, training and personal reference

Resistance, taking drugs on time and missed doses

Two diagrams showing how taking your combination on time keeps drug levels at a safe level and missed doses lead to low drug levels and increase the risk of resistance. 1.  Drug levels with good adherence: 2.  Missing or being …

Do some drugs develop resistance more easily?

From the i-Base guide to changing treatment (2015) Figure 4: How one mutation can stop some drugs working Some drugs stop working after only one mutation. These include NNRTIs (nevirapine, efavirenz, rilpivirine and etravirine), integrase inhibitors (raltegravir) and some nukes (3TC  …

Viral blips and viral rebound

From the i-Base guide to changing treatment. Figure 1. Viral load blips A single blip above 50 is common. It doesn’t mean you need to change treatment. A blip is usually undetectable again on the confirmatory test. Figure 2. Viral …

Time from viral rebound to clinical symptoms

From the i-Base guide to changing treatment (2015) Figure 3. From rebound to symptoms Viral load rebounds. If you stay on the same meds, viral load will continue to rise. Your CD4 count will go down over time. As your CD4 …

HIV life cycle

Diagrams of HIV life cycle showing how different types of drugs work. Picture of HIV life cycle from ‘Introduction to Combination Therapy (2014)‘. Picture from ‘Treatment Training from Advocates‘.

Average CD4 increases by starting CD4 count

This graph shows the average CD4 increases by starting CD4 count over 5 years

When not on treatment, your immune system works in overdrive

How CD4 and viral load are related

CD4 count and viral load with and without treatment CD4 count and viral load with treatment CD4 count and viral load without treatment

Basic organs of the body