HIV i-Base

Drug resistance

UK treatment guidelines (BHIVA) include recommendations to test for antiretroviral drug resistance on diagnosis and prior to starting or changing treatment. Viral load needs to be >500 copies/mL in order for the test to generate a result.

Resistance test results require expert interpretation and are dependent on treatment history and viral load history, especially when previous resistance test results are unavailable.

The following resources provide guidance in use of resistance tests and their interpretation.

A leading US-based resource that maintains a frequently updated online database to help interpret resistance test results.

Medical website linked to the International HIV Drug Resistance Workshop that includes online presentations, drug mutation charts, news, educational modules and an online ‘ask-the-expert’ option.

The December 2010 report from the International AIDS Society–USA (IAS–USA) Drug Resistance Mutations Group. Direct PDF download.

Summary document produced by the Rega Insitute, Belgium in association with the European AIDS Clinical Society (EACS).

Website with interpretation tables developed by HIV resistance researchers in France. Text is in English.

Online interpretation resource from the Max Plank Institute to estimate phenotypic outcomes from genotype results.