Drug interactions between HCV and HIV meds

HCV drugs can be used with many HIV meds but there are a few important potential interactions.

Your doctor needs to check for interactions with any other drugs that you take. This includes prescribed or over-the-counter meds, together with any supplements, herbal remedies and recreational or street drugs.

The online HCV drug interaction database from Liverpool University is free and easy to use.

This site includes interaction charts that use a traffic light summary:

  • Red when drugs should not be used together because of an interaction.
  • Amber for a caution or when additional monitoring is needed.
  • Green when no interaction is likely.

Details on each interaction and reports can be printed for any combination.

Sometimes the recommendation is based on a theoretical risk.

Your doctor needs to know about all drugs you take, whether these are prescribed or over-the-counter, together with any supplements, herbal remedies and recreational or street drugs.

The table below summarises the main known interactions. As only a few combinations have been studied, not being listed does not guarantee there is no interaction.

Drug interactions with recreational drugs

It is also important to be aware that recreational drugs have the potential to interact with HCV drugs, just as with HIV meds.

Although there is currently little information on interactions between HCV treatment and recreational drugs such as cocaine, methamphetamine and ecstasy, this will be important in a real world setting.

Your doctor needs to be aware of all potential interactions when you are using HCV meds.


Full prescribing information and patient information for each DAA.

EASL clinical practice guidelines: Management of HCV infection (2016).

Last updated: 17 August 2017.