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HTB

Latest statistics on continued fall in HIV diagnoses in the UK, caobotegravir injections as PrEP and latest vaccine and treatment news on COVID-19...

Featured HTB: no. 12 – HIV and COVID-19: issue 9 (11 November 2020) 11 November 2020. Related: Editorial.
Featured In Memory: Timothy Ray Brown, the Berlin patient, the first person to be cured of HIV 14 October 2020. Related: In Memory.
Early safety and immune responses in older people using the Oxford vaccine: overall results complicated by dosing error 27 November 2020. Related: Early access, COVID-19: vaccine, COVID-19.
High rates of drug resistance and virological failure among adults with HIV admitted to hospital in Malawi 26 November 2020. Related: Early access, Resistance.
International COVID-19 study launches in Africa but with drugs that have little chance of working (ANTICOV) 25 November 2020. Related: Early access, COVID-19: investigational drugs, COVID-19: research studies, COVID-19.
Disturbingly low HIV knowledge among health workers at London hospital: 80% unaware of U=U, 36% worried about their risk from patients 22 November 2020. Related: Early access, HIV prevention and transmission.
HIV in the UK: diagnoses continued to fall during 2019 but 42% are still late 11 November 2020. Related: HIV prevention and transmission.
i-Base appeal: please support i-Base with £5 or £10 a month 11 November 2020. Related: Editorial.
HIV Therapy Glasgow 2020 11 November 2020. Related: Conference reports, Conference index, Glasgow 2020.
Adverse pregnancy outcomes among Spanish women hospitalised with COVID-19 11 November 2020. Related: Conference reports, Pregnancy, COVID-19: transmission & prevention, COVID-19, Glasgow 2020.
51st World Conference on Lung Health 11 November 2020. Related: Conference reports, Conference index, World Conference on Lung Health 51st 2020.
No increase in adverse birth outcomes with IPT-exposure in pregnancy in two African cohorts 11 November 2020. Related: Conference reports, Pregnancy, TB coinfection, World Conference on Lung Health 51st 2020.
International workshop on clinical pharmacology of HIV, hepatitis, and other antiviral drugs 11 November 2020. Related: Conference reports, Conference index, PK Workshop 2020.
New neonatal liquid formulations of dolutegravir have comparable bioavailability to dispersible paediatric tablet 11 November 2020. Related: Conference reports, Antiretrovirals, Paediatric care, PK and drug interactions, PK Workshop 2020.
EMA issues positive opinion to approve cabotegravir LA/rilpivirine LA injections (Vocabria/Rekambys) as new HIV treatment 11 November 2020. Related: Antiretrovirals.
Two-monthly cabotegravir injections prevent HIV infection in African women: HPTN 084 study recommends early unblinding 11 November 2020. Related: HIV prevention and transmission.
AIDS 2020: Virtual online translated resources 11 November 2020. Related: On the web, IAS COVID-19 virtual 2020.
COVID-19 antibody testing for HIV positive people in the UK: HIV organisations reverse previous exclusion 11 November 2020. Related: COVID-19: HIV and COVID-19 coinfection, COVID-19: diagnostics, COVID-19.
HIV positive people at higher risk of worse outcomes from COVID-19 in UK study 11 November 2020. Related: COVID-19: HIV and COVID-19 coinfection, COVID-19.
Remdesivir given full approval by the US FDA, but on limited data 11 November 2020. Related: COVID-19: investigational drugs, COVID-19.
DSMB stops REGN-COV2 monoclonal antibody study in people with high-flow oxygen or ventilation: implications for UK RECOVERY study 11 November 2020. Related: COVID-19: investigational drugs, COVID-19.
Monoclonal antibody stopped in ACTIV-3 study: bamlanivimab shows lack of benefit in people hospitalised with COVID-19 11 November 2020. Related: COVID-19: investigational drugs, COVID-19.
Early results report 90% efficacy with from Pfizer/BioNTech COVID vaccine 11 November 2020. Related: Special reports, COVID-19: vaccine, COVID-19.
Convalescent plasma: randomised controlled study finds no benefit in moderate stage COVID-19 11 November 2020. Related: COVID-19: investigational drugs, COVID-19.
No survival benefit from remdesivir, hydroxychloroquine, lopinavir/r or interferon-β1a in moderate and severe COVID-19: interim results from the WHO SOLIDARITY study 11 November 2020. Related: COVID-19: investigational drugs, COVID-19.
Future meetings 2020/21 11 November 2020. Related: Future meetings.
HTB no 12 – plus: HIV and COVID-19 bulletin no 9 (11 November 2020) 11 November 2020. Related: PDFs.
HIV Therapy Glasgow 2020 15 October 2020. Related: Conference reports, Conference index, Glasgow 2020.
HTB: no. 11 – HIV and COVID-19: issue 8 (14 October 2020) 14 October 2020. Related: Editorial.
Capsid inhibitor lenacapavir, dosed six-monthly, has high barrier to drug resistance and no cross-resistance to other classes 14 October 2020. Related: Conference reports, Antiretrovirals, Glasgow 2020.
Single doses of MK-8507 reduce viral load by mean –1.5 log and support once-weekly dosing above 80 mg 14 October 2020. Related: Conference reports, Antiretrovirals, Glasgow 2020.
Weight gain with dolutegravir-based ART in Nigerian cohort 14 October 2020. Related: Conference reports, Side effects.
COVID-19: pathogenesis and treatment 14 October 2020. Related: Conference reports, COVID-19: investigational drugs, COVID-19, Glasgow 2020.
EACS guidelines updated (v.10.1) for Glasgow conference 14 October 2020. Related: Conference reports, Guidelines, Glasgow 2020.
International Workshop on Clinical Pharmacology of HIV, Hepatitis, and Other Antiviral Drugs 14 October 2020. Related: Conference reports, PK and drug interactions, PK Workshop 2020.
FTC exposure higher in young transgender men than cisgender controls 14 October 2020. Related: Conference reports, PK and drug interactions, HIV prevention and transmission, PK Workshop 2020.
Levels of long-acting anti-HIV bNAb high in infants after 1 or 2 doses – but not high enough 14 October 2020. Related: Conference reports, Paediatric care, PK and drug interactions, HIV prevention and transmission, PK Workshop 2020.
BASHH 2020 PEP guidelines: online for comment 14 October 2020. Related: Guidelines, HIV prevention and transmission.
New insights into elite control of HIV and a possible case of virus clearance 14 October 2020. Related: Cure research.
US study of HIV positive people with COVID-19 reports worse outcomes with comorbidities and having a CD4 <200 14 October 2020. Related: COVID-19: HIV and COVID-19 coinfection, COVID-19.
Outcomes from COVID-19 in French cohort of 54 HIV positive people on ART 14 October 2020. Related: COVID-19: HIV and COVID-19 coinfection, COVID-19.
Tocilizumab fails to meet clinical endpoints in randomised COVACTA study: other studies continue 14 October 2020. Related: COVID-19: investigational drugs, COVID-19.
COVID-19 reinfection can occur after varying times and with more severe disease 14 October 2020. Related: COVID-19: transmission & prevention, COVID-19.
Transmission from children to family members in US childcare setting 14 October 2020. Related: COVID-19: transmission & prevention, COVID-19.
BHIVA update guidance for HIV care during second wave of COVID-19 14 October 2020. Related: COVID-19: guidelines, COVID-19.
COVID-19 deaths in children and people <21 years old in the US 14 October 2020. Related: COVID-19: paediatrics, COVID-19.
IDSA guidelines on serologic testing for SARS-CoV-2 14 October 2020. Related: COVID-19: diagnostics, COVID-19.
Long COVID: Mild infection and sustained long-term complications 14 October 2020. Related: COVID-19: pathogenesis, COVID-19.
Review paper highlights substandard COVID-19 research in both peer-review journals and pre-review websites 14 October 2020. Related: COVID-19: other news, COVID-19.
Oxford COVID vaccine enrolling HIV positive people at two London sites 11 October 2020. Related: COVID-19: HIV and COVID-19 coinfection, COVID-19: vaccine, COVID-19.