PrEP and side effects

Most people taking PrEP do not get side effects. 

However, like all medicines, some people might get some side effects.

Less than 1 in 10 people report mild nausea, diarrhoea, bloating and headache are reported in the first month. These side effects then usually stop.

Taking PrEP with food can sometimes help.

It is also okay to separate the first double dose by a few hours, if this helps.

Occasionally, PrEP can cause more serious side effects that reduce kidney function and/or bone health.This is why kidney tests are needed when using oral TD/FTC. 

Changes in bone structure are usually small and reverse after stopping TD/FTC. This is similar to a commonly used oral contraceptive but might be important if you are younger than 18 when bones are still developing. Bone strength was not fully reversed after a year in one study in adolescents aged 15 to 19.

PrEP does not increase the risk of bone fractures.

Last updated: 1 August 2025.