March/April HTB online
1 April 2013. Related: News.
This new issue of HTB is now online.
This issue includes our first 18 reports from CROI 2013 – the most important annual HIV medical conference.
We include Richard Jefferys’ elegant analysis of functional cure in an HIV infected infant: a case that attracted wide media coverage but divided opinion among researchers.
A monthly injection, protected rhesus macaques after repeated rectal exposure to SHIV compared to placebo: offering the potential to overcome the adherence obstacles associated with oral PrEP, reported in the VOICE trial.
An abundance of paediatric studies include the ARROW study, conducted in Uganda and Zimbabwe, in collaboration with the UK MRC has produced a rich set of data to help guide children’s treatment. Other reports include the development of lopinavir/ritonavir for infants and young children, PK in children, and a review of tenofovir use.
TB studies include Nathan Geffen on the much-anticipated RIFAQUIN trial using once weekly dosing in the continuation treatment phase and a study combining TB urine tests with Xpert to improve diagnostic sensibility.
We also include a review of statin use in HIV and studies looking for the mechanisms to explain why medical male circumcision reduces the risk of catching HIV.
Non-CROI news includes:
- ARV news includes the EU opinion for Stribild (Quad) and food requirements of Eviplera and paediatric use of darunavir
- A detailed look at the question of “When to start?”
- Updated US guidelines (starting earlier, but on limited evidence)
- An update on the START trial – almost enrolled, results due 2016
- Publication reviews on anal cancer, biomarkers for osteonecrosis and cognitive disorders (in France)
Two of the i-Base treatment guide have been updated and are included as supplements to this issue of HTB.
Both are already online and are available free, including in bulk to UK clinics. Please order online in the regular way.