Daily PrEP

Most PrEP studies have used daily PrEP.

Taking PrEP every day makes sure that there are protective drug levels 24 hours a day, 7 days a week, even if you don’t have sex.

This means you can have sex anytime, without planning for PrEP.

• If you generally have sex every week, daily PrEP might be an easier routine.
• After the first week, daily dosing needs at least 6-7 doses a week (unless you can use 2:1:1 dosing). Guidelines later in 2024 might recommend less strict adherence. This could make PrEP easier for women and trans and non-binary people.

• Quick-start daily dosing using a double dose for the first dose. This will protect you within two hours. The pre-dose is important for the highest protection. But if you miss or are late with the pre-dose, start with a double dose as soon as possible. 
• Once on PrEP, continue taking daily PrEP for at least six days each week. This might change when guidelines are updated.
• There is currently no data about neovaginal sex. Starting with a double dose and then using daily dosing is therefore a conservative recommendation.

Last updated: 1 February 2024.