Glossary

antigen – a protein found on the surface of a virus or bacteria. It is recognised by the immune system which then generates antibodies.

preclinical refers to the early development stage for a new drug, before any testing on humans. This includes they laboratory and animal tests. Preclinical studies will not always show what will happen when people use the drugs, but can provide a guide to serious problems that could occur.

fusion inhibitor – a type of HIV drug (an entry inhibitor). Fusion inhibitors stops HIV ‘fusing’ to a CD4 cell. T-20 (enfuvirtide, Fuzeon) is only currently licensed fusion inhibitor.

Drug targets in the virus life cycle.

toxicity – medical word for side effect, the potential harm a drug can cause.

jaundice – a common symptom of hepatitis where increased levels of bilirubin lead to a yellowing of the skin or eyes.