fold-change – a term relating to drug resistance after a phenotype resistance test.
4-fold resistance (also called a 4-fold loss in sensitivity) means you need to use four times the dose to get the same reduction in viral load.
Glossary
Selected words and phrases
partially active – the HIV treatment in question will work against this virus but this is reduced compared to wild-type HIV. This is the same as partial resistance, or intermediate resistance etc.
phenotype — relating to how an organism behaves, based on how its genotype relates to the environment. Phenotypic resistance tests look at whether HIV continues to grow in a test tube after increasing concentrations of a drug are added. See genotype.
Minimum Effective Concentration (MEC) – the lower level of a drug in the body that will still be effective.
Cmax – highest concentration of a drug after a dose.