clinical failure – when you develop new symptoms and illnesses even though you are on treatment. See virological failure.
Glossary
Selected words and phrases
DAA (direct acting antiviral) – new hepatitis C drugs that work directly against the hepatitis C virus (HCV).
The following links are to UK prescribing information for DAA combinations plus ribavirin.
Elbasvir/grazoprevir
https://bnf.nice.org.uk/drugs/elbasvir-with-grazoprevir/
Sofosbuvir/ledipasvir
https://bnf.nice.org.uk/drugs/ledipasvir-with-sofosbuvir/
Glecaprevir/pibrentasvir
https://bnf.nice.org.uk/drugs/glecaprevir-with-pibrentasvir/
Sofosbuvir/velpatasvir
https://bnf.nice.org.uk/drugs/sofosbuvir-with-velpatasvir/
Sofosbuvir/velpatasvir/voxilaprevir
https://bnf.nice.org.uk/drugs/sofosbuvir-with-velpatasvir-and-voxilaprevir/
Ribavirin (RBV)
https://bnf.nice.org.uk/drugs/ribavirin/
Additional information is available from the MHRA website.
https://products.mhra.gov.uk/
diarrhoea – when stools (faeces) is less than firm. This can range from loose to being very watery. As a medical condition it is usually also associated with needing to go to the toilet more frequently.
For example, this is commonly defined as three or more liquid/watery faeces over 24 hour period.
See this information from the i-Base guide to side effects for ways to manage and treat diarrhoea.
https://i-base.info/guides/side/diarrhoea
HCV – hepatitis C, a virus that causes liver disease.
selective pressure – this is when a factor in the environment causes one type of organism to develop and grow in preference to another. With HIV drug resistance, the presence of a drug exerts selective pressure for resistance to develop. It is based on evolution and the concept of ‘survival of the fittest’ theory developed by Charles Darwin.