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Glossary

Selected words and phrases

A feeling that your bowl not completely empty even though it is empty. A medical definition is “a sensation of incomplete bowel evacuation despite an empty rectum”.

The marvels of latin and medicine – words for everything…

integrase inhibitor – a type of HIV drug that stops HIV genetic material from ‘integrating’ into the DNA in a cell.

This is a relatively new family of HIV drugs.

Raltegravir, elvitegravir and dolutegravir are all integrase inhibitors.

Food and Drug Administration (FDA) – the US FDA is the government organisation that is responsible for approving and regulating human and animal medicines in the US. It is also responsible for the safety of other products including foods, cosmetics and tobacco.

See: www.fda.gov

long-term non-progressor (LTNP) – An HIV positive person whose CD4 count stays above 500 copies/mm3 with very low viral load for more than five years, without using ART.

Some LTNPs have kept their CD4 count above 500 for more than 10-15 years without ART. Recent guidelines suggest the LTNPs should still strongly consider using ART. This is because ongoing HIV replication is still likely to increase the risk of serious illnesses, even at low viral load levels,

Because CD4 counts gradually fall in LTNPs, just very slowly, a more accurate term is long-term slow-progressors (LTSPs).

Elite controllers (ECs) are a sub-group of LTSP who also maintain undetectable viral load (less than 50 copies/mL) without ART. See: elite controller.

antigen – a protein found on the surface of a virus or bacteria. It is recognised by the immune system which then generates antibodies.