Summary of Product Characteristics (SPCs) – detailed information about a drug provided by the maker that is approved by the European Regulatory Agency (EMEA/CPMP). Also called EPARs.
Glossary
Selected words and phrases
codon – the word for the junction on genetic material (DNA or RNA) occupied by three nucleotides (or bases) to form an amino acid. In HIV it is most used when refering to drug resistance. There is an amino acid at each codon and the codons are numbered (starting from 1) for each section of the HIV gene. For example the mutation M184V in RT refers to a mutation change at codon 184 in the reverse transcriptase gene.
carcinoma – cancer in tissues covering or lining organs of the body, such as the skin, the uterus, the lung, or the breast.
publication bias – the tendency for published results to be different to other trials. For example, trials that show a positive effect are more likely to be reported and published than trials that find no effect.
Cmax – highest concentration of a drug after a dose.