Glossary

abstract – in research, a short summary of a study (usually about 350 words)

major mutation – a drug resistance mutation that have a big impact on whether a drug continues to work. This used to be called a primary mutation.

long-term non-progressor (LTNP) – An HIV positive person whose CD4 count stays above 500 copies/mm³ with very low viral load for more than five years, without using ART.

Some LTNPs have kept their CD4 count above 500 for more than 10-15 years without ART. Recent guidelines suggest the LTNPs should still strongly consider using ART. This is because ongoing HIV replication is still likely to increase the risk of serious illnesses, even at low viral load levels,

Because CD4 counts gradually fall in LTNPs, just very slowly, a more accurate term is long-term slow-progressors (LTSPs).

Elite controllers (ECs) are a sub-group of LTSP who also maintain undetectable viral load (less than 50 copies/mL) without ART. See: elite controller.

intrapartum refers to the last stages of during pregnancy when the baby is born. These are labour and delivery (or chold birth). Intrapartum can refer to both the baby and the mother.

See: antepartum and postpartum.

lumbar puncture – taking a sample of spinal fluid by inserting a needle into the body at the base of the spine. Also called a spinal tap.