Glossary

Area Under the Curve (AUC) – total exposure to drug over the dosing period.

NNRTI – Non-Nucleoside Reverse Transcriptase Inhibitor, a type of HIV drug – also called ‘non-nuke’.

Efavirenz, nevirapine, rilpivirine, etravirine and doravirine are all NNRTIs.

Drug targets in the virus life cycle.

Listing of NNRTIs.

integrase inhibitor – a type of HIV drug that stops HIV genetic material from ‘integrating’ into the DNA in a cell.

This is a relatively new family of HIV drugs.

Raltegravir, elvitegravir and dolutegravir are all integrase inhibitors.

platelet – a blood cell that helps with blood clotting.

blip – small, occasional increase in viral load.