elite controller (EC) – if your viral load stays undetectable for more than five years without ART you are an elite controller.
Elite controllers also have a very good CD4 count (always above 500 cells/mm3) that stays at a similar level over many years.
Even with this good immune response, ART is still generally recommended in the long-term.
This is because over decades – some ECs have been undetectable for more than 20 years – there is a concern that low level HIV in different body compartments like the brain, might lead to accumulative serious damage that isn’t easy to detect until it is too late.
This is a real concern, though evidence is limited because of the rarity of ECs.
See: long-term slow progressor (LTSP)/long-term non-progessor (LTNP).
obstetrics – a branch of medicine that refers to the care of women during pregnancy.
event-based dosing – See EBD.
nuke – a common term for NRTI
TasP (Treatment as Prevention) – a term to emphasise the impact that HIV drugs (ART) has on dramatically reducing the chance of HIV transmission.
ART is firstly for the health of the HIV positive person. But having an undetectable viral load on ART makes it so difficult to transmit HIV that the risk gets so close to zero that it is effectively zero.
For example, in the PARTNER study, nearly 900 couples had sex more than 58,000 times without condoms, without any transmissions. Each couple included one person who was HIV positive with an undetectable viral load on ART and one person who was HIV negative. ZERO transmissions.
