Glossary

minor mutation – a drug resistance mutation that have a big impact on whether a drug continues to work. This used to be called a secondary mutation.

adherence – taking your medicine at the right time each day and in the right way.

• Adherence and why it is so important.
• Adherence tips – easy ways to help.

NRTI – Nucleoside Reverse Transcriptase Inhibitor, a type of HIV drug – also called ‘nuke’ or ‘nucleoside analogue’.

3TC (lamivudine). abacavir, AZT, FTC (emtricitabine), d4T (stavudine), ddI (didanosine) all belong to this class.

Tenofovir DF and tenofovir alafenamide (TAF) are a nucleotide analogues which is similar enough to be counted as part of this class.

Drug targets in the virus life cycle.

IRIS (immune reconstitution inflammatory syndrome) – illnesses that occur when HIV treatment is started when the CD4 count is very low.

IRIS occurs because the immune system quickly becomes stronger and identifies infections that it was previously too weak to fight.

IRIS can occur in 1 in 4 (25%) people who start with a CD4 count under 50 cells/mm³.

Although the symtoms are serious, IRIS can usually be easily managed.

Common infections related to IRIS include TB and CMV.

grade/grading – the grade of hepatitis infection refers to the amount of inflammation in liver tissue, found by a biopsy. It is usually measured on the Ishak scale from 1-18) where 0 is none and 18 is the maximum. See staging.