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Glossary

Selected words and phrases

NRTI – Nucleoside Reverse Transcriptase Inhibitor, a type of HIV drug – also called ‘nuke’ or ‘nucleoside analogue’.

3TC (lamivudine). abacavir, AZT, FTC (emtricitabine), d4T (stavudine), ddI (didanosine) all belong to this class.

Tenofovir DF and tenofovir alafenamide (TAF) are a nucleotide analogues which is similar enough to be counted as part of this class.

Drug targets in the virus life cycle.

autoantibody – abnormal antibodies produced against the body’s own tissues.

undetectable – an amount smaller than a test can measure. For viral load tests, this means below 400 or, more commonly, below 50 copies/mL, depending on the make of test. In research laboratories, some very sensitive tests can measure down to 1 copy/mL.

nucleotide – the building blocks of the genetic code (DNA/RNA). Also called a base.

free radical – a chemical produced after a molecular reaction, often containing oxygen, that has one ‘free’ unpaired electron on its outer surface. This makes it able to react and damage other cells, and perhaps increase progression of cardiovascular disease, cancers and aging. See antioxidant.