Glossary

quantitative (in a study) – where what is being measured has a numerical value or fits a pre-defined scale or range of responses.

uneven distribution – a term in statistics where most results fall to the left (positive skewness) or right (negative skewness) of the middle of the range.

reverse transcriptase – an enzyme unique to HIV. It is used to convert single-strand RNA into double-strand DNA. This is needed before HIV’s genetic material can be integrated in the human DNA. HIV drugs that stop this process are called reverse transcriptase inhibitors (RTIs).

diabetes – when the body either does not produce enough insulin (a hormone that helps the body turn sugar into energy) or is not responding to insulin (insulin resistance). There are two main types of diabetes and they have different mechanisms and treatments.

Type-1 is mainly reported in children but can also occur in adults and is linked to genetic risks.

Type-2 is mainly reported in adults (but increasingly in children) and is more commonly related to lifestyle factors including diet, exercise, weight/BMI. Some medications can increase the risk of Type-2 diabetes.

Diabetes can also be a side effect, including from some early HIV drugs, and this is sometimes referred to as a third type. This is because it was primarily caused as a side effect, rather than being driven by either lifestyle factors or genetics.

Other commonly-used drugs that can affect glucose regulation include corticosteroids and some drugs to reduce high blood pressure, or lipids.

PI (protease inhibitor) – a type of HIV drug.

HIV protease inhibitors include atazanavir, darunavir, fosamprenavir, indinavir, nelfinavir, lopinavir/r (Kaletra), ritonavir, saquinavir and tipranavir.

Drug targets in the virus life cycle

Different protease inhibitors have been developed to treat hepatitis C.