Glossary

ETR (end of treatment response) – having an undetectable HCV viral load at the end of HCV treatment. See SVR.

randomised controlled trial (RCT) – a type of research study that produces very high quality results. RCTs are often called gold-standard – ie the best evidence.

Study participants are randomly assigned to one of more study arm. One or more arms might use new drugs and another (the control arm) maybe uses the standard of care, or maybe a placebo.

See: randomise

coinfection – having more than one infection, eg HIV and TB, or HIV and hepatitis C.

NRTI – Nucleoside Reverse Transcriptase Inhibitor, a type of HIV drug – also called ‘nuke’ or ‘nucleoside analogue’.

3TC (lamivudine). abacavir, AZT, FTC (emtricitabine), d4T (stavudine), ddI (didanosine) all belong to this class.

Tenofovir DF and tenofovir alafenamide (TAF) are a nucleotide analogues which is similar enough to be counted as part of this class.

Drug targets in the virus life cycle.

Hypertension is the medical name for high blood pressure (BP). Blood pressure is measured as two numbers ie 120/80. The first number is systolic BP – the pressure when your heart beats. The second number is diastolic BP, which is the pressure when you heart rests between beats.

Target range for BP is usually 120/80. Drugs to reduce BP are sometimes recommended if this is above 130/85 or 140/90. This also depends on other risk factors for heart disease, including age, sex, ethnicity ajd other health factors.

Hypertension increases the risk of a heart attack or stroke, particularly when diastolic BP is high.

See: Hypotension (low blood pressure).