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Glossary

Selected words and phrases

Immune reconstitution inflammatory syndrome – see: IRIS

clinical cut-off (CCO) – a test result that is associated with an impact on clinical care. With resistance tests a lower CCO is the level below which a drug is still sensitive or active. This is often set at a 20% loss of activity (compared to wild-type HIV). An upper CCO is the level above which the drug is not considered active (ie resistant). This is often set at an 80% loss of activity (compared to wild-type HIV).

duration of ruptured membranes – time between when the mother’s waters break and the actual delivery.

sarcoma – medical term for cancer that affects bone, cartilage, fat, muscle, blood vessels, skin or other connective tissue.

Cancer: lymphoma and sarcoma.

Area Under the Curve (AUC) – total exposure to drug over the dosing period.