Reports from the workshop

Although this workshop has a wealth of studies focussing on basic science and more obscure aspects of resitance, research with the most important impact on clinical management is always presented to this meeting first.

Studies reported include:

• Integrase inhibitors and resistance

• Treatment failure and tropism changes in maraviroc trial related to previously undetected CXCR4, rather than a mutational shift from CCR5

• Mechanisms of failure to CCR5 inhibitors is not explained by mutation in the V3 loop, cross-resistance between CCR5 inhibitors is likely

• Higher risk of resistance using lopinavir/r monotherapy

• Macaque study shows similar protection from rectal exposure using 2-hour pre- and 24-hour post exposure prophylaxis with tenofovir plus FTC compared to daily regimen

• Thirteen NNRTI mutations linked to resistance to etravirine (TMC-125)

The abstract book from the Workshop is available to download:

http://www.informedhorizons.com/resistance2007/pdf/AbstractBook_RW2007_final.pdf PDF file 1.2 Mb