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Conference reports

Early ART and testing HIV negative with rapid HIV tests

On-demand dosing for PrEP is highly effective in French expanded access programme

New IPERGAY analysis shows on-demand PrEP dosing works with less frequent sex

9th IAS Conference on HIV Science (IAS 2017)

HIV pipeline drugs: IAS 2017 update

Darunavir/cobicistat/FTC/TAF: 24-week interim results from phase 3 switch study

Phase 3 results with bictegravir FDC: a new integrase inhibitor combined with FTC/TAF

Doravirine/3TC/TDF compared to efavirenz/FTC/TDF as first-line ART

Continued viral suppression with long-acting cabotegravir/rilpivirine injections: 96-week LATTE-2 results

Reduced-dose darunavir is safe and effective in switch study

MK-8591: further compelling early results for both treatment and prevention

Dolutegravir outperforms lopinavir/ritonavir second-line: interim results from the DAWNING study

Preliminary results on dolutegravir use in pregnancy are reassuring

Low dose efavirenz (EFV400) can be used during pregnancy

Stillbirth rate in HIV positive women in UK/Ireland is double that of the general population

Swaziland nearly halves HIV incidence in five years

Gay men with undetectable viral load do not transmit HIV: Opposites Attract study supports U=U

HIV remission news from IAS 2017

Publications launched at IAS 2017

9th International Workshop on HIV Paediatrics, 21–22 July 2017, Paris

Chewable raltegravir tablets can be crushed and dispersed in liquid for young children

Inconsistencies between real-world data from UK and Ireland and EU recommendations for new antiretrovirals in pregnancy

18th International Workshop on Clinical Pharmacology of Antiviral Therapy, 14-16 June 2017, Chicago

Dolutegravir pharmacokinetics in pregnancy

High rates of of undocumented efavirenz-related side effects in Uganda

11th INTEREST Workshop, 16-19 May 2017, Lilongwe, Malawi

Increased risk of ART failure after low-level viraemia in a large South African cohort

Option B+ Malawi

24th Conference on Retroviruses and Opportunistic Infections (CROI 2017), 13-16 February 2017, Seattle

Impressive HIV pipeline at CROI 2017

Paediatric HIV: CROI 2017

23rd Annual Conference of BHIVA, 4-7 April 2017, Liverpool

Drop in HIV incidence in gay men: frequent testing, early ART and PrEP

Prompt/early ART: Dean Street pilot project reports 75% uptake

Potential for phylogenetic analysis to show direction of HIV transmission

Community presentations: dental care, HIV awareness and access to formula milk

Initiatives for earlier HIV diagnosis: opt-out ER and home testing

No new HIV cases in 398 people using PrEP at Dean Street clinic

Other selections and webcasts

24th Conference on Retroviruses and Opportunistic Infections (CROI 2017), 13-16 February 2017, Seattle

Dose reduction potential of nanoparticle ARV formulations confirmed in humans

VRC01 in HIV-exposed newborns: first results support monthly injections for those at risk through breastfeeding

Raltegravir pharmacokinetic targets met in high-risk HIV-exposed infants

Tenofovir alafenamide exposure is modestly higher in children than adults

New HIV diagnoses in children in UK and Ireland continue to decline

World Health Organisation paediatric dosing tool

Pre-ART drug resistance in rural South Africa but limited clinical impact with good adherence

Immune-based therapy canakinumab reduces inflammatory markers in HIV positive people on ART

Significant interaction between once-weekly isoniazid/rifapentine and daily dolutegravir: study stopped due to toxicity

Increased risk of IRIS with integrase inhibitors reported in two studies

Breakthrough for treating XDR-TB and ameliorating TB-IRIS

PrEP in pregnancy does not increase poor birth outcomes

HIV cure research and basic science: capsules from CROI 2017

24th Conference on Retroviruses and Opportunistic Infections (CROI 2017), 13-16 February 2017, Seattle

Pharmacokinetics and full phase 2 results for bictegravir, a new integrase inhibitor

New NNRTI doravirine is non-inferior to darunavir/r in phase 3 treatment naive study

NRTI GS-9131 resurfaces at CROI 2017: in vitro sensitivity to nuke-resistant HIV

Dolutegravir exposure increases when fixed dose combination tablets are crushed

Pharmacokinetics, safety and efficacy of dolutegravir in very young children

Efavirenz, tenofovir and emtricitabine associated with fewest adverse birth outcomes in Botswana

Adverse pregnancy outcomes and risk factors in the PROMISE trial

Women on lopinavir/ritonavir-based regimens at conception at higher risk of preterm delivery in UK study

No increase in adverse birth outcomes with maternal TDF/FTC in US study

Dolutegravir monotherapy studies halted due to integrase resistance: dual therapy studies continue

No evidence of accelerated brain ageing in HIV positive people on effective ART

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