Early drugs being studied for COVID-19
27 March 2020. Related: Treatment strategies, COVID-19: investigational drugs, COVID-19.
Treatment strategies
Four days on, three days off is NOT as effective as daily ART: French study results need to be interpreted with caution
23 August 2019. Related: Conference reports, Treatment strategies.
Dolutegravir-based first-line non-inferior to efavirenz-based ART but associated with substantial weight gain: results from the ADVANCE study
23 August 2019. Related: Conference reports, Antiretrovirals, Treatment strategies, Side effects.
bNAb research at CROI 2019: vaccine, prevention, treatment and cure…
30 April 2019. Related: Conference reports, Treatment strategies, HIV prevention and transmission, Cure research.
Dolutegravir/3TC dual ART is as effective at lowest viral load cut-off as triple therapy in GEMINI studies
28 March 2019. Related: Conference reports, Antiretrovirals, Treatment strategies.
Same-day ART is effective in San Francisco Rapid-ART clinic
28 March 2019. Related: Conference reports, Antiretrovirals, Treatment strategies.
Viral reservoir can explain persistent low level viraemia with good adherence on ART
12 March 2019. Related: Conference reports, Treatment strategies.
Dolutegravir non-inferior to low dose efavirenz in real-life African study conducted in Cameroon
13 November 2018. Related: Conference reports, Antiretrovirals, Treatment strategies.
Dual bNAb maintains viral suppression for median 21 weeks off-ART
13 November 2018. Related: Conference reports, Antiretrovirals, Treatment strategies.
Dolutegravir monotherapy: still no longer recommended in either research or clinical practice
24 August 2018. Related: Conference reports, Treatment strategies.
Once-daily reduced dose darunavir/ritonavir (400 mg/100 mg) is non-inferior to twice-daily lopinavir/ritonavir in South African switch study
3 August 2018. Related: Conference reports, Treatment strategies.
M184V mutation associated with increased risk of viral blip but not viral failure with 3TC-based dual therapy
16 April 2018. Related: Conference reports, Treatment strategies, Resistance.
Early ART is not associated with a higher risk of HIV drug resistance
5 January 2018. Related: Treatment strategies, Resistance.
Dolutegravir-based dual therapy as switch option in multiple studies
28 November 2017. Related: Conference reports, Treatment strategies.
Switch study shows F/TAF non-inferior to continuing abacavir/3TC
28 November 2017. Related: Conference reports, Antiretrovirals, Treatment strategies.
Dolutegravir outperforms lopinavir/ritonavir second-line: interim results from the DAWNING study
10 August 2017. Related: Conference reports, Antiretrovirals, Treatment strategies, Treatment access.
Immune-based therapy canakinumab reduces inflammatory markers in HIV positive people on ART
24 April 2017. Related: Conference reports, Treatment strategies, Basic science and immunology.
Increased risk of IRIS with integrase inhibitors reported in two studies
24 April 2017. Related: Conference reports, Antiretrovirals, Treatment strategies, Opportunistic infections and complications.
Dolutegravir monotherapy studies halted due to integrase resistance: dual therapy studies continue
27 February 2017. Related: Conference reports, Treatment strategies.
Simplifying HIV treatment: dual therapy works but monotherapy with either boosted-PIs or dolutegravir does not
29 November 2016. Related: Conference reports, Treatment strategies.
Atripla three days a week for two years: pilot switch study reports undetectable viral load with better bone, kidneys and sleep
1 October 2016. Related: Conference reports, Treatment strategies.
Four day a week ART: sub-optimal drug levels but few virological failures
1 October 2016. Related: Conference reports, Treatment strategies.
ZERO: no linked HIV transmissions in PARTNER study after couples had sex 58,000 times without condoms
1 August 2016. Related: Conference reports, Treatment strategies, HIV prevention and transmission.
CD4:CD8 ratio is more sensitive marker of risk than CD4 counts in analysis from START study
1 August 2016. Related: Conference reports, Treatment strategies.
Treatment in primary HIV infection is significantly more likely to normalise CD4:CD8 ratio
1 August 2016. Related: Conference reports, Treatment strategies.
Further results using dolutegravir monotherapy: urgent need for controlled studies
1 February 2016. Related: Antiretrovirals, Treatment strategies.
Potential economic impact of dolutegravir/3TC dual therapy
1 February 2016. Related: Antiretrovirals, Treatment strategies.
First-line ART with dolutegravir plus 3TC: 24-week early results
1 December 2015. Related: Conference reports, Antiretrovirals, Treatment strategies.
Achieving viral suppression with HIV multi-drug resistance: peg-interferon and valaciclovir as part of rescue therapy
1 December 2015. Related: Conference reports, Antiretrovirals, Treatment strategies, Resistance.
Four reasons IAS 2015 will be a milestone HIV conference: a personal view
1 August 2015. Related: Conference reports, Antiretrovirals, Treatment strategies, HIV prevention and transmission.
Starting HIV treatment at high CD4 counts protects against both AIDS and non-AIDS events: overall and in subgroup analyses of START study
1 August 2015. Related: Conference reports, Antiretrovirals, Treatment strategies.
The option for same day antiretroviral therapy on diagnosis: the future model for HIV care
1 August 2015. Related: Conference reports, Treatment strategies, Treatment access, Treatment advocacy, Other news.
Low dose boosted atazanavir is non-inferior to standard dose in Thai treatment optimisation study: LASA
1 August 2015. Related: Conference reports, Treatment strategies.
HPTN 052: no HIV transmissions on effective ART but only limited data on viral failure and drug resistance
1 August 2015. Related: Conference reports, Treatment strategies, HIV prevention and transmission.
Early HIV treatment and isoniazid prophylaxis: why TEMPRANO results do not yet support universal ART at CD4 counts >500
24 March 2015. Related: Conference reports, Treatment strategies, TB coinfection.
Weekend-off ART is non-inferior to continuous ART in young people taking efavirenz-based regimens: results from BREATHER study
24 March 2015. Related: Conference reports, Treatment strategies, Paediatric care.
Gender differences in use of cardiovascular disease-related interventions: D:A:D study
1 December 2014. Related: Conference reports, Treatment strategies, Women's health, Side effects.
Higher ART coverage is associated with lower HIV infection rates in a multi-country analysis
1 August 2014. Related: Conference reports, Treatment strategies, HIV prevention and transmission.
No difference in overall anaemia rate with reduced dose AZT
1 August 2014. Related: Conference reports, Treatment strategies, Treatment access.
Fit for purpose: treatment optimisation 2014
19 July 2014. Related: Pipeline report, Fit for purpose, Treatment strategies.
50% of UK seroconverters start ART within 1.4 years of infection: treating during primary infection should be a patient choice
27 May 2014. Related: Conference reports, Antiretrovirals, Treatment strategies.
PIVOT study: further analysis from five-year PI/r monotherapy strategy study
27 May 2014. Related: Conference reports, Antiretrovirals, Treatment strategies.
Hospitalisation among elite controllers
27 May 2014. Related: Conference reports, Treatment strategies.
Viral load rebound rate of 35% using ritonavir-boosted PI monotherapy: results of five-year PIVOT study
24 March 2014. Related: Conference reports, Antiretrovirals, Treatment strategies.
Dual therapy less effective at high viral load: NEAT 001 study with raltegravir/darunavir/r
24 March 2014. Related: Conference reports, Antiretrovirals, Treatment strategies.
Atazanavir, raltegravir and darunavir virologically equivalent in naive patients but significant differences for tolerability: results from ACTG 5257
24 March 2014. Related: Conference reports, Antiretrovirals, Treatment strategies.
NNRTI resistance found in 12% of people stopping treatment with undetectable viral load: implications for stock-outs
24 March 2014. Related: Conference reports, Treatment strategies, Resistance.
Southern African treatment guidelines retain CD4 threshold of 350 for starting ART (2013)
1 October 2013. Related: Treatment strategies, Treatment access, Guidelines.
Executive summary and research policy recommendations
30 June 2013. Related: Pipeline report, Antiretrovirals, Treatment strategies, Diagnostics, Hepatitis coinfection, TB coinfection.
Retrofitting for purpose: treatment optimisation 2013
30 June 2013. Related: Pipeline report, Fit for purpose, Treatment strategies.
The tuberculosis treatment pipeline
30 June 2013. Related: Pipeline report, Treatment strategies, TB coinfection.
Why the “when to start” question is complex and informed by limited evidence: a response to Dr Myron Cohen
1 April 2013. Related: Treatment strategies, Guidelines.
START study increases sample size: additional 600 participants to be older than 35
1 April 2013. Related: Antiretrovirals, Treatment strategies.
Treatment in seroconversion maintains HIV specific immune responses similar to long term slow progressors
1 August 2011. Related: Conference reports, Treatment strategies, Basic science and immunology.
Monitoring treatment in resource limited settings: results from PHPT-3 and Stratall ANRS12110/ESTER trials
1 August 2011. Related: Conference reports, Treatment strategies, Treatment access.
DART: high rates of viral suppression after five years and a single CD4 test with a threshold of 250 cells/mm3 could reduce unnecessary switching
1 August 2011. Related: Conference reports, Treatment strategies, Treatment access.
Lopinavir/r monotherapy used as second-line therapy in resource-limited settings
1 August 2011. Related: Conference reports, Treatment strategies, Treatment access.
Dose optimisation: 50 mg ritonavir-boosting, 3TC dosing and raltegravir once-daily
1 May 2011. Related: Conference reports, Antiretrovirals, Treatment strategies.
Switching boosted-PIs to raltegravir
1 October 2010. Related: Conference reports, Antiretrovirals, Treatment strategies.
Scaling up: what to do first?
1 October 2010. Related: Conference reports, Treatment strategies, Guidelines.
Tablets more acceptable than syrups in the ARROW trial
26 August 2010. Related: Conference reports, Antiretrovirals, Treatment strategies, Paediatric care.
Current or former injecting drug use is not related to earlier switch or discontinuation of HAART compared to non-IDU patients since 1999
2 October 2007. Related: Treatment strategies.
HIV viraemia may explain increased risk of cardiovascular disease, death and other serious events in patients interrupting treatment in the SMART trial: new study to randomise patients with CD4 counts >500 to start immediate treatment or defer to <350 cells/mm3
3 September 2007. Related: Conference reports, Treatment strategies.
CD4 increases in immunological non-responders despite suppressive therapy following switch to nuke-sparing regimen of ATZ/SQV/r
3 September 2007. Related: Conference reports, Treatment strategies.
Autologous stem cells transplant (ASCT) in HIV-positive individuals with a relapsed non-Hodgkins lymphoma (NHL) or Hodgkins disease (HD)
10 June 2006. Related: Treatment strategies.
