The University of Colorado’s Courtney Fletcher scrutinizes reports on antiretroviral pharmacology from the latter half of 2005 as part of the Clinical Care Options “Clinical Management Series.”

The Importance of Pharmacokinetic Factors in Successful Antiretroviral Therapy

http://clinicaloptions.com/HIV/Management%20Series/Pharmacokinetics.aspx

The review includes analysis of the following topics:

• Melt-extrusion formulation of lopinavir/ritonavir
• Drug absorption and gastric acid-reducing agents
• Differential effects of tipranavir/ritonavir on drug transport and metabolism
• Fluticasone and ritonavir
• Didanosine and food
• Integrating pharmacokinetics into treatment decisions
• Applying pharmacokinetic considerations for drugs with different elimination half-lives
• Inhibitory quotient as a determinant of virologic response