HTB

Liverpool Drug interactions website updates

Liverpool University newsletter

The Liverpool University drug interaction website now includes the following updates.

New antiretroviral: albuvirtide

The long-acting fusion inhibitor albuvirtide (Aikening) to the interaction checker. Albuvirtide is administered once weekly by intravenous infusion and has marketing approval to treat HIV in China. In is also being used in research studies in the US. 

New comedications

Based on user suggestions the following drugs have been added to the interaction checker:

Benazepril (Hypertension and Heart Failure Agents)

Eletriptan (Anti-migraine Agents)

Etidocaine (Anaesthetics and Muscle Relaxants)

Ferrous fumarate (Herbals/Supplements/Vitamins)

Filgrastim (Other)

Lenalidomide (Cancer Therapies)

Minaxolone (Anaesthetics and Muscle Relaxants)

Moxonidine (Hypertension/Heart Failure Agents)

Piperacillin (Antibacterials)

Tazobactam (Antibacterials)

Tinidazole (Antibacterials)

Trastuzumab (Cancer Therapies)

Trastuzumab emtansine (Cancer Therapies)

Vinorelbine (Cancer Therapies)

Please please use this feedback link if you have other suggestions:
https://www.hiv-druginteractions.org/suggestions

Comedication name changes

Some alternative/older names have been added that have another name in use in certain countries. You will now be able to find these drugs by searching for the alternative name, in addition to the name commonly in use in the UK.

Methotrexate changed to Methotrexate (Amethopterin)

Clomipramine changed to Clomipramine (Chlorimipramine)

Bupropion changed to Bupropion (Amfebutamone)

Clarification of interactions with vitamins

Finally, some of the names of comedications in the supplements class have been changed to make it clearer whether or not the interaction is due to a component of a multivitamin. The following vitamins can now be selected either as a single vitamin supplement or as part of a multivitamin:

Ascorbic acid (Vitamin C), Colecalciferol (Vitamin D3), Cyanocobalamin (Vitamin B12), Folic acid, Iodine, Nicotinamide (Niacinamide), Phytomenadione (Vitamin K), Pyridoxine (Vitamin B6), Retinol (Vitamin A), Riboflavin (Vitamin B2), Thiamine (Vitamin B1), Tocopherol (Vitamin E).

In particular, this makes a difference to oral integrase inhibitors, which are susceptible to chelation.

Links to other websites are current at date of posting but not maintained.