Reports and journals
2 February 2010. Related: On the web.
PLoS Medicine
Volume 6(11) November 2009
The unintended consequences of clinical trials regulations.
McMahon AD et al.
http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000131
Alex McMahon and colleagues critique the International Conference on Harmonisation (ICH) guidance on good clinical practice (GCP), arguing that it is having a disastrous effect on noncommerical randomised clinical trials in Europe.
Effects of genital ulcer disease and HSV-2 on the efficacy of male circumcision for HIV prevention: analyses from the Rakai trials.
Gray RH et al.
http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.
pmed.1000187
Ron Gray and colleagues analyse data from two circumcision trials in Uganda to assess how HSV-2 status and genital ulcer disease affect the procedures ability to reduce HIV infection.