PLoS Medicine

Volume 6(11) November 2009

The unintended consequences of clinical trials regulations.

McMahon AD et al.

http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000131

Alex McMahon and colleagues critique the International Conference on Harmonisation (ICH) guidance on good clinical practice (GCP), arguing that it is having a disastrous effect on noncommerical randomised clinical trials in Europe.

Effects of genital ulcer disease and HSV-2 on the efficacy of male circumcision for HIV prevention: analyses from the Rakai trials.

Gray RH et al.

http://www.plosmedicine.org/article/info%3Adoi%2F10.1371%2Fjournal.pmed.1000187

Ron Gray and colleagues analyse data from two circumcision trials in Uganda to assess how HSV-2 status and genital ulcer disease affect the procedure’s ability to reduce HIV infection.