Treatment training manual

AIDS-defining infections for CDC clinical categories

Conditions included in the 1993 CDC AIDS surveillance case definition were laast updated in 2008.

The few changes are underlined in the list below.*

  • Bacterial infections, multiple or recurrent *
  • Candidiasis of bronchi, trachea, or lungs.
  • Candidiasis, esophageal (thrush) – but not mouth.
  • Cervical cancer, invasive.
  • Coccidioidomycosis, disseminated or extrapulmonary.
  • Cryptococcosis, extrapulmonary.
  • Cryptosporidiosis, chronic intestinal (greater than 1 month’s duration).
  • Cytomegalovirus disease (CMV) (other than liver, spleen, or nodes).
  • Cytomegalovirus retinitis (CMV) (with loss of vision).
  • Encephalopathy, HIV-related.
  • Herpes simplex: chronic ulcer(s) (greater than 1 month’s duration); or bronchitis, pneumonitis, or esophagitis.
  • Histoplasmosis, disseminated or extrapulmonary.
  • Isosporiasis, chronic intestinal (greater than 1 month’s duration).
  • Kaposi’s sarcoma (KS).
  • Kaposi sarcoma
  • Lymphoid interstitial pneumonia or pulmonary lymphoid hyperplasia complex*
  • Lymphoma, Burkitt’s (or equivalent term).
  • Lymphoma, immunoblastic (or equivalent term).
  • Lymphoma, primary, of brain.
  • Mycobacterium avium complex or M. kansasii, disseminated or extrapulmonary.
  • Mycobacterium tuberculosis (TB), any site (pulmonary or extrapulmonary).
  • Mycobacterium, other species or unidentified species, disseminated or extrapulmonary.
  • Pneumocystis jirovecii pneumonia (PCP)– formerly pneumocystis carinii).*
  • Pneumonia, recurrent.
  • Progressive multifocal leukoencephalopathy (PML).
  • Salmonella septicemia, recurrent.
  • Toxoplasmosis of brain.
  • Wasting syndrome due to HIV.

Source: Center for Disease Control (CDC) –  MMWR (2008)

Last updated: 1 January 2023.